Arsenic trioxide as a novel anti-glioma drug: a review

Table 1 Studies on arsenic trioxide-induced glioma cell death

First author	Cell line	Does (μM)	Time	Findings	Refs
Kanzawa	U373, U87MG, U251, GB1, A-172, T98G	1,2,4	72 h	Autophagy	[19, 20]
Eun Hee Kim	U373MG, U87MG, U251MG, U343, U251N, T98G	4,5,6	24 h	No apoptosis	[30]
Ye Cheng	U87MG, U251, SHG44, C6	2,4,8	48 h	Apoptosis	[17]
Naomi Haga	A172, T98G	1,10,50	48 h	A172: apoptosis; T98G: no apoptosis	[40]
Yuanyuan Sun	C6, 9L	0.5–8	24,48,72 h	Apoptosis	[41]
Primon, M	U87MG	2,5,10,20	72 h	2 μM:autophagy; More than 10 μM: apoptosis	[21]
Karsy, M	U87MG	0.5,1,2,4,16	24 h	More than 4 μM: apoptosis	[23]
Majid Zaki Dizaji	U87MG	1,2	48 h	Apoptosis	[63]
G.-B. WANG	U87MG	4,6,8	72 h	Apoptosis	[24]
Shiguang Zhao	U87MG,T98G	1,2,4,8	12,24,48 h	Apoptosis, the effect of T98 is greater than U87	[28]
Hui-Wen Chiu	U118MG	2,4,6,8	12,18,24,36 h	Autophagy and apoptosis	[25]
Tain-Junn Cheng	U118	1,5,10,25,50	24 h	Autophagy	[24]
Hui-Wen Chiu	U118-MG	2	24 h	Autophagy	[27]
Yuanyan Wei	SHG44	2,4,6	24 h	Apoptosis	[36]

ISSN: 1689-1392