Fig. 2
From: The nuclear receptor 4A family members: mediators in human disease and autophagy
Structural organization of NRs. Most NRs consist of several domains: an N-terminal region with AF1, which is important for its interaction with co-regulators and other transcription factors; a highly conserved zinc-finger DBD, which allows the receptor to bind specific response elements; a variable hinge domain; a ligand-binding domain (LBD) with AF2; and a highly variable C-terminal domain