From: Beyond K48 and K63: non-canonical protein ubiquitination
Process/effect | Ub linkage(s) | USP/DUB | E2(s) | E3(s) | Substrate(s) |
---|---|---|---|---|---|
Mitophagy | K6/K11/K48/K63 | USP30 | Â | Parkin | |
Mitophagy | K6 | USP30 | Â | Â | TOM20 [19] |
DDR | K6 | Â | Â | BRCA1-BARD1 | BRCA1-BARD1 [21] |
DDR | K6 | Â | Â | BRCA1-BARD1 | [22] |
DDR | K6 | Â | Â | RNF8 | Nbs1 [26] |
DDR | K6/K48/K63 | Â | Â | HUWE1 | Chk1 [25] |
Many | K6 | Â | Â | HUWE1 | |
D/S | K6 | Â | Â | HUWE1 | Mfn2 [27] |
n.d | K6/K11/K48/K63 | Â | UBCH7/UBE2L3 | RNF144A, RNF144B | [27] |
D/S | K6 | Â | Â | MGRN1 | |
D/S | K6/K11 | Â | Â | CBLC | EGFR [33] |
D/S | K6 | Â | Â | HUWE1 | Ubl4A [28] |
D/S | K6 | Â | Â | UBE4A | Viperin [29] |
DNA binding | K6/K11/K29 | OTUD1 | Â | Â | IRF3 [36] |
DDR | K11 | Â | UBE2S | RNF8 | H2A/H2AX [37] |
D/S | K11 | Â | UBE2F | SAG-CUL5 | NOXA [54] |
D/S | K11 |  | UBE2S | SAG/RBX2 | β-TrCP1 [55] |
D/S | K11 |  | UBE2S |  | β-Catenin [60] |
D/S | K11/ K29 |  |  | EDD | β-Catenin [59] |
D/S | K11 | Â | UBE2S | Â | SOX [56] |
PPI | K11 | Â | UBCH5 | c-IAP1 | RIP1 [58] |
D/S | K11 | Â | UbcD1 | Cul1-Slimb | |
D/S | K11 | Â | UBE2S, UBCH10 | APC/C | |
D/S | K11 | Cezanne | UBE2S | APC/C | Cyclin B, Securin [69] |
D/S | K11 | Cezanne |  |  | HIF1α [70] |
D/S | K11 | Cezanne | Â | Â | E2F1 [71] |
D/S | K11 | USP19 |  |  | HIF1α [147] |
Innate immunity | K11 | USP19 | Â | Â | Beclin-1 [62] |
D/S | K11 | USP8 | Â | Â | Caspase-1 [64] |
D/S | K11 | USP8 | Â | Â | SQSTM1 [65] |
Innate immunity | K11 | Â | Â | RNF26 | STING [52] |
D/S | K11/K48 | Â | Â | UBR5 | TIP60 [49] |
D/S | K11/K48 | RAD6 | Â | KCMF1-UBR4 | [48] |
D/S | K11/K48 | Â | Â | SKP1-Cullin-Fbx21 | Ci [51] |
Plant development/ stress response | K11 | UBC22 | Â | Â | |
PPI | K27 | Â | Â | RNF168 | H2A [111] |
D/S | K27 | Â | Â | fbxo3 | IRF3, IRF7 [83] |
PPI | K27 | PSMD14 | Â | Â | IRF3 [84] |
Innate immunity | K27 | Â | Â | AMFR | STING [85] |
Innate immunity | K27 | USP13, USP21 | Â | Â | |
Innate immunity | K27 | Â | Â | RNF185 | cGAS [86] |
Innate immunity | K27 | USP19 | Â | Â | TAK1 [93] |
Protein activation | K27 | Â | Â | ITCH | BRAF [96] |
Localization | K27 | Â | Â | ITCH | TIEG1 [97] |
D/S | K27/K6 | Â | Â | NEDD4 | Beclin-1 [98] |
PPI | K27/K48 | Â | Â | HACE1 | Optineurin [99] |
PPI | K27 | Â | Â | HACE1 | YB-1 [101] |
Innate immunity | K27 | Â | Â | TRIM23 | NEMO [104] |
Innate immunity | K27 | Â | Â | Â | Rhbdd3, NEMO [105] |
Autophagy | K27 | Â | Â | TRIM23 | TRIM23 [102] |
Innate immunity | K27 | Â | Â | TRIM26 | TRIM26 [103] |
Protein activity | K27, K27/K29 | Â | Â | Hectd3 Hectd3 | Stat3, Malt1 [106] |
Innate immunity | K27 | Â | Â | TRIM40 | RIG-I, MDA5 [107] |
Innate immunity | K27 | Â | Â | MARCH8 | MAVS [108] |
Innate immunity | K27 | Â | Â | TRIM21 | MAVS [109] |
PPI | K27 | Â | Â | Â | NS3 [89] |
D/S | K27 | Â | Â | RNF114 | NS4B [90] Nsp12 [91] |
Protein activity | K27 | Â | Â | TRIM62 | CARD9 [112] |
Aggregation | K27/K29 | Â | Â | WSB1 | LRRK2 [115] |
Aggregation | K29/K6/K27 | Â | Â | TRAF6 | HTT [116] |
Protein activity | K29 | Â | Â | Trim13 | TRAF6 [117] |
PPI | K29, K29/K33 | Â | Â | Smurf1 Smurf1 | Axin [120] UVRAG [121] |
Innate immunity | K29 | Â | Â | SKP1-Cullin-Fbx21 | ASK1 [123] |
Autophagy | K27/K29 | Â | Â | RNF34 | MAVS [113] |
D/S | K29/K48 | Â | Ubc4p | Ufd4p | [124] |
D/S | K29 | Â | Â | ITCH/AIP4 | DTX [125] |
Protein activity | K29 | Â | UBE3C | Â | Rpn13 [126] |
Protein activity | K29/K33 | USP9X | Â | Â | ARK5/NUAK1, MARK4 [127] |
Signaling | K33 |  |  | Cbl-b, Itch | TCR-ζ [131] |
Innate immunity | K33 | USP38 | Â | Â | TBK1 [132] |
Innate immunity | K33 | Â | Â | RNF2 | STAT1 [133] |
 | K33 |  |  | RNF152 | RagA [130] |
Trafficking | K33 | Â | Â | KLHL20 | Coronin7 [135] |
D/S | K33 | Â | Â | LZTR1 | RAS [138] |
Localization | K33 | Â | Â | Â | LC3B, SQSTM1 [136] |
Autophagy | K29, K33 | ZRANB1 | Â | RNF166 |