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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: Deficiency of αII-spectrin affects endothelial cell–matrix contact and migration leading to impairment of angiogenesis in vitro

Fig. 7

Knockdown of αII-spectrin destabilizes cell projection. a through c The number of cell extensions (filopodias) and their maximum size and lifetime (stability) were evaluated in HMEC-1 cells which were transfected or not with plasmids expressing GFP and Nr shRNA or Sp shRNA. The number of filopodia per cell is not significantly affected in cells transfected with shRNA targeting αII-spectrin (a; Bartlett’s test ANOVA, p = 0.8487), but their length is significantly reduced (b; Bartlett’s test, p = 0.0076) and their lifespan is dramatically decreased (c; Mann Whitney test, p = 0.0006)

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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