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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis

Fig. 1

Biogenesis of eRNA. NamiRNA forms a complex with nAGO2 and p300, which activate enhancer markers such as H3K27ac, H3K4me3, and H3K4me1 at active enhancers making the enhancer recognizable to the Pol II. TFs and proteins such as P-TEFb, PAF1, and SPT6 bind to Pol II and other enhancers associated with components like p53 and P300 CBP and BRD4. Pol II is activated following the phosphorylation of Pol II CTD and abundant PAS at the TSS of active enhancers. Pol II bidirectionally transcribes the enhancer and its halter by the integrator complex cleaving the eRNA transcripts

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