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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis

Fig. 2

Biogenesis of NamiRNAs in the nucleus and cytoplasm. Pol II transcribes miRNA coding genes in the same loci as enhancers. MPC process the ds-miRNA into hairpin loop structures. Nuclear AGO2 and RNAi factors Dicer and TRBP process ds-miRNA into NamiRNAs in the nucleus. Alternatively, cytoplasmic produced miRNAs which were transcribed from genes with enhancer associated properties are activated by a RISC-like structure in the cytoplasm. The activated NamiRNAs in the cytoplasm are transported back into the nucleus via FXR1 to perform their activation and enhancing function

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