Fig. 5
From: Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis
The proposed model of eRNAs and NamiRNAs cooperatively enhancing and activating target genes. NamiRNAs form a complex with AGO2 and p300; they bind to enhancers and activate markers such as H3K27ac and H3K27me3, which attract RNA polymerase to recognize and translate the enhancer. Transcribed RNAs bind to p300 and other proteins to activate enhancer features at the target gene’s promoters. The attracted NamiRNAs then attach to the gene’s promoter and subsequently activate the target gene’s expression