Fig. 2

Exemplary PET images of MMIA-CML (a) and MMIA-HSA (b) nanoparticles radiolabeled with ⁶⁴Cu acquired in a murine model at one week after surgical ligation of the right femoral artery. One hour after radiolabeled probe injection, animals were subjected to the imaging session. Nanoparticle targeted at RAGE notably bonded to the muscle tissue’s ischemic area (yellow arrows) versus the opposite non-ischemic hindlimb; neither ischemic nor non-ischemic hindlimbs exhibited recognizable accumulation of untargeted, control MMIA-HSA