Fig. 4

Binding studies using RAGE-targeted (MMIA-CML) and non-targeted (MMIA-HSA) nanoparticles. Murine muscle tissue sections from ischemic and non-ischemic hindlimbs at 1 week after HLi were incubated with 1 µM MMIA-CML or MMIA-HSA. Quantitative measurement proved that ischemic muscle tissue fragments one week after surgical ligation of the femoral artery showed explicit RAGE-targeted probe uptake versus non-ischemic dissected tissue fragments. (*) - p < 0.05. Data represent mean and mean squared error