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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

Fig. 4

Mechanism of pyroptosis. (1) In the classical pathway, PAMPs/DAMPs activate assembly of the NLRP3 complex and sequentially cleave and activate caspase 1 to cause the maturation and release of IL-1β and IL-18 or to activate gasdermin to form a pore structure that leads to pyroptosis. (2) In the nonclassical pathway, activation of caspase 4, 5 and 11 cleaves GSDMD and causes pyroptosis. The two pathways engage in crosstalk with each other via panxinin-1 and GSDMD

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