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Table 1 molecular targets of miR-338 during tumor progressions

From: Molecular interactions of miR-338 during tumor progression and metastasis

Study Year Type Gene Target Samples Function
Liu [20] 2018 Lung Circ-0001649 miR-338-5p 53 NT* A549, H358, H1299, and H1581 cell lines Inhibited cell proliferation and migration
Zhu [24] 2020 Renal Circ-AKT1 miR-338-3p 70 NT 768-O, A498, ACHN, Caki-1, and OS-RC-2 cell lines Induced cell proliferation, migration, and EMT
Wang [28] 2020 Myeloma Circ-0007841 miR-338-3p 41 patients and 41 healthy controls (plasma) H929 and OPM2 cell lines Induced cell proliferation
Du [32] 2020 Colorectal Circ-RAE1 miR-338-3p 80 NT HCT116, SW620, HT29, and SW480 cell lines Induced cell migration
Xu [35] 2020 Lung Circ-0000326 miR-338-3p 100 NT A549, SPC-A1, H1299, and H1975 cell lines Induced tumor progression
Shu [38] 2020 Thyroid Circ-HIPK3 miR-338-3p 10 NT K1, CAL-62, and TPC-1 cell lines Induced progression and invasion
Liu [39] 2020 Liver Circ-104566 miR-338-3p 87 NT SK-HEP-1, HLE, SNU449, Hep-3B, and Huh7 cell lines Induced tumor progression
Xiong [41] 2019 Glioma Circ-SMO742 miR-338-3p 10 NT A172 and U-87MG cell lines Induced cell proliferation
Pu [43] 2020 Liver Circ-0000092 miR-338-3p 40 NT Hep3B, LM3, MHCC97L, Sk-hep1, and HepG2 cell lines Induced tumor progression
Qian [47] 2020 Cervical Circ-HIPK3 miR-338-3p 45 NT HeLa, CaSki, SiHa, C-33A, C-4I, and SW756 cell lines Induced EMT
Jin [48] 2020 Gastric Circ-HIPK3 miR-338-3p 31 NT MGC803 and BGC823 cell lines Induced cell migration
Xiang [49] 2020 Osteosarcoma Circ-CCDC66 miR-338-3p 12 NT SW1353 and U2OS cell lines Induced tumor invasion
Yang [50] 2020 Colorectal Circ-0137008 miR-338-5p 30 NT HT29, HCT116, HCT8, LOVO, SW480, and SW620 cell lines Inhibited cell proliferation and migration
Yan [56] 2017 Esophageal SNHG1 miR-338-3p 56 NT 6 primary cell culture Induced cell proliferation
Zhang [60] 2019 Neuroblastoma SNHG1 miR-338-3p 33 NT SK-N-SH and SK-N-AS cell lines Induced cell proliferation and migration
Li [65] 2019 Colorectal SNHG15 miR-338-3p 203 NT HCT116, SW620, LOVO, SW480, and 293 T cell lines Induced cell proliferation
Zhang [66] 2019 Prostate SNHG15 miR-338-3p LNCAP, DU145, and PC3 cell lines Induced cell proliferation and EMT
Liu [69] 2018 Ovarian LINC00460 miR-338-3p 98 NT SKOV3, A2780, OVCAR, and HO-8910 Increased cell proliferation and EMT
Hu [70] 2020 Prostate LINC00173 miR-338-3p 124 NT DU145, PC3, and LNCAP cell lines Induced tumor cell progression
Wan [71] 2020 Glioma LINC00525 miR-338-3p U87, MO59K, U118, Hs683, and LN-18 cell lines Regulated migration and EMT
Lu [72] 2020 Gastric LINC-00689 miR-338-3p 40 NT HGC-27, SGC-7901, MGC-803, and AGS Induced cell growth and EMT
Feng [74] 2020 Leukemia NEAT1 miR-338-3p 32 patients 32 healthy controls KG-1, HL-60, THP-1, and U937 cell lines Inhibited cell growth and migration
Jing [76] 2019 Lung CRNDE miR-338-3p 84 NT A549, H1299, SPCA1, and H358 cell lines Induced tumor progression
Song [79] 2020 Esophageal BANCR miR-338-3p 40 NT KYSE450 and KYSE510 cell lines Inhibited tumor progression
Luan [80] 2018 Cervical XLOC-006390 miR-338-3p 20 NT SiHa, HeLa, CaSki, C-41, and C-33A cell lines Induced tumor progression
Chen [82] 2020 Lung SBF2-AS1 miR-338-3p 56 NT A549, H1650, and H1975 cell lines Induced tumor growth
Ji [83] 2019 Liver DSCAM-AS1 miR-338-3p 48 NT HepG2, Hep3B, Huh7, and SMMC7721 cell lines Induced tumor progression
Li [85] 2019 Oral OIP5-AS1 miR-338-3p 38 NT SCC9, SCC15, Ca9-22, and HSU3 cell lines Increased cell proliferation, migration, colony formation, and in vivo growth
Ma [89] 2018 Glioma miR-338-5p FOXD1 130 NT U251 cell line Inhibited cell proliferation
Hua [90] 2017 Cervical miR-338-3p MACC1 67 NT HeLa and CaSki cell lines Inhibited cell proliferation
Jia [91] 2019 Osteosarcoma miR-338-3p RUNX2, CDK4 MG-63 and U2OS cell lines Inhibited cell proliferation and migration
Peng [96] 2014 Gastric miR-338-3p NRP1 41 NT SGC-7901, HGC-27, AGS, MKN-45, and N87 cell lines Inhibited cell proliferation and migration
Ding [98] 2019 Lung miR-338-3p NRP1 55 NT A549, HCC827, and H226 cell lines Inhibited colony formation and cell migration
Liu [99] 2015 Oral miR-338-3p NRP1 24 NT TCa-8113 and SCC-15 cell lines Inhibited cell proliferation and invasion
Song [112] 2018 Gastric miR-338-3p EPHA2 AGS cell line Inhibited proliferation and migration
Niu [116] 2019 Ovarian miR-338-3p WNT2B 54 NT SKOV3, A2780, and IOSE-80 cell lines Induced cisplatin response
Xue [120] 2014 Colorectal miR-338-3p SMO 40 NT HT29, LOVO, Caco2, and SW-620 cell lines Inhibited cell migration
Huang [121] 2011 Liver miR-338-3p SMO 36 NT Hep3B, SK-HEP-1, Huh7, Bel-7402, and SMMC-7721 cell lines Inhibited tumor invasion
Guo [124] 2014 Gastric miR-338-3p PREX2a 53 NT AGS and BGC-823 cell lines Inhibited tumor progression
Chen [125] 2013 Neuroblastoma miR-338-3p PREX2a 18 NT SH-SY5Y cell line Inhibited cell proliferation and migration
Besse [128] 2016 Glioblastoma miR-338-5p NDFIP1, PPP2R5a 40 NT A172, T98G, and U87MG cell lines Inhibited cell proliferation
Liu [132] 2019 Lung miR-338-3p AKT A549 cell line Inhibited cell proliferation
Sui [133] 2017 Thyroid miR-338-3p AKT3 48 NT 8505c, TPC-1, and SW1736 cell lines Inhibited cell proliferation, migration, and in vivo growth
Lu [137] 2018 Cervical miR-338-3p ATF2 30 NT Siha, HeLa, C33A, and Me180 cell lines Inhibited autophagy
Chu [141] 2019 Colorectal miR-338-5p PIK3C3 66 NT SW480 and HCT166 cell lines Induced tumor invasion
Zhang [145] 2017 Lung miR-338-3p IRS2 40 NT A549, H1299, SPCA1, and H358 cell lines Inhibited cell proliferation and migration
Wang [147] 2015 Liver miR-338-3p FOXP4 30 NT HepG2 and Hep3B cell lines Inhibited cell proliferation
Tong [152] 2017 Renal miR-338-3p SOX4 48 NT 786-O, ACHN, Caki-1, and Caki-2 cell lines Inhibited colony formation and cell migration
Jin [154] 2015 Breast miR-338-3p SOX4 32 NT MCF-7, MDA-MB-231, BT-549, and MDA-MB-453 cell lines Inhibited colony formation, in vivo growth, and cell migration
Huang [155] 2015 Gastric miR-338-3p ZEB2 20 NT AGS, MKN-45, and NCI-N87 cell lines Inhibited EMT
Lu [157] 2019 Colorectal miR-338-3p MACC1 15 NT SW480 and 293 T cell lines Inhibited cell proliferation and migration
Zhang [158] 2019 Melanoma miR-338-3p MACC1 60 NT A375 and G361 cell lines Inhibited cell proliferation and migration
Zou [159] 2018 Colorectal miR-338-3p MACC1 98 NT SW480, SW620, HT29, HCT116, and SW1116 cell lines Inhibited tumor progression
Zhang [160] 2019 Ovarian miR-338-3p MACC1 105 NT Inhibited cell proliferation and migration
Shang [161] 2016 Glioma miR-338-3p MACC1 39 T and 17 N U251 and U87 cell lines Induced cisplatin sensitivity
He [166] 2020 Breast miR-338-3p ZEB1 148 NT MCF7 and HCC1937 cell lines Inhibited cell proliferation and EMT
Shan [167] 2015 Nasopharyngeal miR-338-3p HIF1A 5 NT CNE-1, CNE-2, 5-8F, and 6-10B cell lines Inhibited cell migration and proliferation
Xu [168] 2014 Liver miR-338-3p HIF1A 15 NT HepG2, SMMC-7721, BEK-7402, Hep3B, and Huh7 cell lines Induced sorafenib response
He [170] 2020 Lung miR-338-3p NFATc1 20 NT A549, H1650, SPCA-1, H460, H226, and H1299 cell lines Inhibited cell proliferation
Zhang [174] 2019 Bladder miR-338-3p ETS1 39 NT J82, 5637, and T24 cell lines Inhibited cell proliferation and EMT
Li [176] 2018 Glioma miR-338-5p TSHZ3 35 NT U87 and U251 cell lines Increased invasiveness
Wen [178] 2015 Ovarian miR-338-3p RUNX2 54 NT SKOV3, OVCAR3, and A2780 cell lines Inhibited cell proliferation, migration, and in vivo growth
Duan [181] 2019 Breast miR-338-3p MORC4 30 NT MCF7 and MDA-MB-231 cell lines Inhibited cell migration
Li [185] 2013 Gastric miR-338-3p SSX2IP 66 NT SGC-7901, NCI-N87, BGC-823, AGS, KATO-III, SNU-1, MKN-28, and MKN-45 cell lines Inhibited cell proliferation and in vivo growth
Lei [191] 2017 Glioblastoma miR-338-5p EFEMP1 15 NT U251, A172, U-118, and U87 cell lines Inhibited cell proliferation and migration
Chen [197] 2016 Lung miR-338-3p ITGB3 115 NT A549, NCI-H292, NCI-H460, NCI-H446, and NCI-H1299 cell lines Inhibited tumor invasion
Li [200] 2018 Renal miR-338-3p KIFC1 58 NT 786-O, 769-P, and OS-RC-2 cell lines Inhibited cell proliferation and migration
Cao [202] 2018 Osteosarcoma miR-338-3p AHSA1 20 NT MG-63, Saos2, and HOS cell lines Inhibited EMT and invasion
Xiao [207] 2018 Liver miR-338-3p SPHK2 39T and 21N HepG2, SMMC-7721, and BEL7402 cell lines Inhibited cell proliferation
Zhang [209] 2017 Lung miR-338-3p SPHK2 34 NT H460, H1299, A549, SPC-A-1, and Calu-3 cell lines Inhibited cell proliferation
Han [216] 2017 Glioblastoma miR-338-3p PKM2 U87, LN229, and SNB19 cell lines Inhibited cell proliferation
Zhang [217] 2016 Ovarian miR-338-3p PKM2 HO-890, A2780, CoC1, CoC2, SKOV3, and Caov-3 cell lines Inhibited cell proliferation
Sun [220] 2018 Gastric miR-338-3p PTP1B 12 NT MKN-45 and MGC-803 cell lines Inhibited cell proliferation
  1. *Normal and Tumor tissues