Fig. 1

β-Elemene-affected ceRNA axis identified via microarray and bioinformatics analysis a Determination of the IC50 of β-elemene in primary human airway granulation fibroblasts (PHAGF) used in subsequent experiments including microarray analysis. b CCK‐8 assay-detection of the proliferation of primary human airway fibroblasts (PHAF), PHAGF and β-elemene-treated PHAGF. ^*P < 0.05, ^#p < 0.05. c A volcano plot was generated to show the differential expression distribution via microarray analysis. d Heatmap of the top 10 differentially expressed lncRNAs and mRNAs in PHAGF after β-elemene treatment. Green indicates down-regulation, red indicates up-regulation. e A dotplot depicts the top 10 suppressed pathways with the highest enrichment scores identified by KEGG pathway enrichment analysis in β-elemene-treated PHAGF. f Differentially expressed mRNAs were mapped to the focal adhesion pathway network via KEGG mapper tools. Red solid-line box represents down-regulated gene; large red dashed box indicates the ILK/Akt sub-pathway. g Visualization of ILK-centered ceRNA regulatory network constructed from bioinformatic database