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Table 1 Incidence and risk factors for burn-induced HO (BIHO) reported in large scale burn centers within the past decade

From: Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formation

Reference

Dataset of the study

Total simple size

Number of patients with BIHO

Incidence of BIHO (%)

Age of patients with BIHO (years)

Male (%) of patients with BIHO

Burn %TBSA

Location with frequency of BIHO

Time to incidence of BIHO

Factors associated with BIHO

Levi et al. [21]

Six burn centers in America

2797

98

3.5

41.25

81 (83.0)

47

NA

NA

1. Arm burns requiring skin grafts (OR = 96.4a)

2. Burn greater than 30% TBSA (OR = 11.5a)

3. Number of trips to operating room (OR = 1.32a)

4. Number of days on ventilator (OR = 1.034a)

Thefenne et al. [23]

Single burn center in France

805

32

4.0

47

20 (62.5)

48.5

Elbow (50%)Shoulder (20.3%)Hip (17.6%) Knee (10.8%) Wrist (1.3%)

NA

1. Use of fluidized bed (OR = 39.6a)

2. Curare use (OR = 24.1a)

3. Pulmonary infection (OR = 21.5a)

4. Cutaneous infection (OR = 7.5a)

5. Length of stay in the burns ICU (OR = 1.1a)

6. Mean total burn area (OR = 1.1a)

7. Mean depth of burns (OR = 1.1a)

Orchard et al. [24]

Single burn center in Australia

337

19

5.6

43

16 (84.2)

46

Elbow (89%) Knee and shoulder (less common).

Clinical: 37 (30–40) days Radiological: 49 (38–118) days

1. A greater % TBSA

2. Inhalation injury

3. Use of mechanical ventilation

4. Number of surgical procedures

5. Sepsis

6. Longer time to active movement (OR = 1.48a)

  1. Age (years) of patients with BIHO was shown by median; burn % TBSA was shown by mean or median
  2. NA not available
  3. aIndependent risk factors for BIHO that are statistically significant in multivariate analysis