Table 1 All of the long non-coding RNAs associated with Doxorubicin response in different cancers

Breast cancer (BC)

 BC

Resistance

XIST

miR-200c-3p /ANLN

MDA-MB-231/ADM and MDA-MB-231 cell lines

XIST up regulated ANLN by sponging miR-200c-3p and inhibited cell proliferation as well as promoted apoptosis

[34]

 BC

Resistance

Linc00152

-

40 NT*

MDA-MB-231 and MCF-7 cell lines

Knockdown of Linc00152 suppressed tumor growth, cell migration, invasion, and chemo-resistance

[41]

 BC

Resistance

Linc00518

miR-199a/MRP1

30 NT

MCF-10A, MCF-7/ADR and MCF-7 cell lines

Linc00518 Knockdown suppressed MRP1 expression and induced cell apoptosis

[44]

 BC

Resistance

HOTAIR

PI3K/AKT

MCF-7 and DOXR-MCF-7 cell lines

HOTAIR suppressed PI3K/AKT pathway, reduced cell survival and promoted apoptosis

[48]

 BC

Resistance

Linc00668

SND1

HMEC-hTERT, MCF-10A, MCF-7, T47D, MDA-MB-231, HS578t, and 293T, SUM149, and SUM159 cell lines

Linc00668 interacted with SND1 and regulated SMAD2/3/4 expression, and also decreased invasion, self-renewal, and chemo-resistance

[54]

 BC

Resistance

DCST1-AS1

ANXA1

MDA-MB-231, BT-549, T-47D, and MCF7 cell lines

DCST1-AS1 targeted ANXA1 and induced EMT

[61]

 BC

Resistance

LINC00160

C/EBPβ/TFF3

47 NT

MCF‐7, MCF‐7/Tax, BT474, BT474/Dox and MCF10A cell lines

LINC00160 knockdown reduced cell migration and invasion

[64]

 BC

Resistance

LINP1

CASP9/BAX

MDA-MB-231, MDA-MB-231/5FU, MDA-MB-231/DOX, MDA-MB-468 and MCF7 cell lines

LINP1 knockdown suppressed tumor growth and metastasis as well as promoted apoptosis

[65]

 BC

Resistance

H19

CUL4A /ABCB1/MDR1

MCF-7 cell lines

H19 up regulated CUL4A and ABCB1/MDR1 genes

[69]

 BC

Resistance

H19

PARP-1

63 NT

MCF-7 and MCF-7/Dox cell lines

Knockdown of H19 increased PARP-1 expression and induced cell death

[71]

Osteosarcoma (OS)

 OS

Resistance

TUG1

AKT

Saos-2 and MG-63 cell line

Polydatin inhibited TUG1/AKT axis and proliferation and promoted apoptosis

[83]

 OS

Resistance

FOXC2-AS1

FOXC2

68 NT

MG63, SaoS2 and HOS cell lines

FOXC2-AS1 facilities ABCB1 expression by increasing FOXC2 expression

[86]

 OS

Resistance

FOXC2-AS1

ABCB1

MG63, SaoS2 and U-2OS cell lines

Silencing of FOXC2-AS1 and ABCB1 repressed tumor growth

[89]

 OS

Resistance

OIP5-AS1

miR-137-3p

56 tumor tissues and 16 normal tissues

hFOB1.19, MG63, and MG63/DOX cell lines

OIP5-AS1 knockdown inhibited proliferation and metastasis

[93]

 OS

Resistance

OIP5‐AS1

miR‐200b‐3p

80 patients

MG63, KHOS and U2OS cell lines

OIP5‐AS1 sponged miR‐200b‐3p and regulated FN1 expression. Overexpression of FN1 contributed to the sensitivity of OS cells to doxorubicin

[97]

 OS

Resistance

SNHG12

miR-320a / MCL1

32 doxorubicin-resistant patients and 32 doxorubicin-sensitive patients

MG-63, U2OS, HOS, SAOS-2 and hFOB cell lines

SNHG12 modulated Wnt/β-catenin pathway, so inhibited miR-320a expression and promoted MCL1 expression

[103]

 OS

Resistance

LINC00426

miR-4319

MG63, KHOS, U2OS, MG63/DXR, and KHOS/DXR cell lines

Knockdown of LINC00426 significantly decreased cell viability and proliferation

[104]

 OS

Sensitivity

CTA

miR-210

30 patients

Saos-2, U-2OS, MG-63 and MG-63/DOX cell lines

Overexpression of CTA reduced autophagy and promoted apoptosis

[105]

 OS

Sensitivity

FENDRR

ABCB1/ ABCC1

80 patients

MG63, SaoS2, HOS and MG63/DXR cell lines

FENDRR down regulated ABCB1 and ABCC1 as well as suppressed DOX resistance and induced cells apoptosis

[108]

Gastric cancer (GC)

 GC

Resistance

HOTAIR

miR-217

30 NT

BGC-823, SGC-7901, KATO-3, MGC-803, and GES1

Knockdown of HOTAIR inhibited cell proliferation and migration

[116]

 GC

Sensitivity

UCA1

PARP

77 NT

GES-1, BGC-823 and SGC7901 cell lines

Knockdown of UCA1 caused repression of proliferation in cancerous cells

[120]

 GC

Resistance

UCA1

miR-27b

28 patients

SGC-7901, SGC-7901/ADR, SGC-7901/DDP and SGC-7901/FU

Knockdown of UCA1 induced the expression of miR-27b, resulting in reduction of Bcl2 expression and promotion of CASP3 expression

[123]

 GC

Resistance

D63785

miR-422a

21 patients

GES-1, SGC7901, MGC803, BGC823, NCI-N87, HEK293 and HEK293T cell lines

Reduced lncR-D63785 expression repressed proliferation, invasion, and metastasis

[128]

 GC

Resistance

NEAT1

–

76 NT

SGC790, GES-1, SGC7901/ADR cell lines

NEAT1 repressed cell proliferation, apoptosis, and invasion

[131]

 GC

Resistance

MRUL

P-gp

SGC7901/ADR, SGC7901/VCR, SGC7901/ADR, and SGC7901 cell lines

MRUL depletion induced apoptosis

[132]

Leukemia and lymphoma

 AML

Resistance

KCNQ1OT1

miR-193a3p / Tspan3

74 patients and 37 healthy subjects

HS-5, HL60, HL60/ADR, K562, and K562/ADR cell lines

KCNQ1OT1 knockdown suppressed the cell proliferation and invasion

[139]

 AML

Resistance

TUG1

miR-34a

36 patients and 23 healthy subject

HS-5, HL60, and HL60/ADR

TUG1 knockdown overcame ADR resistance of AML by epigenetically enhancing miR-34a expression

[141]

 AML

Resistance

HOXA-AS2

miR-520c-3p / S100A4

48 patients

U937, U937/ADR, THP-1, and THP-1/ADR cell lines

HOXA-AS2 acted as ceRNA of miR-520c-3p and induced S100A4 expression. Knockdown of HOXA-AS2 expression significantly suppressed cell proliferation

[144]

 AML

Resistance

Linc00239

PI3K/ATK/mTOR

HL-60 and KG-1 cell lines

Linc00239 activated PI3K/ATK/mTOR pathway. Linc00239 knockdown suppressed the cell proliferation and migration

[147]

 CML

Sensitivity

FENDRR

HuR

K562 and KCL22 cell lines

FENDER overexpression promoted cell apoptosis and suppressed cell proliferation

[155]

 BL

Resistance

MCM3AP-AS1

miR-15a/EIF4E

41 patients

B-NHL cell line

MCM3AP-AS1 knockdown decreased cell viability and increased apoptosis

[160]

Hepatocellular carcinoma (HCC)

 HCC

Resistance

MALAT1

miR-216b

BEL-7402 and BEL-7402/5-FU cell lines

MALAT1 knockdown decreased proliferation and migration

[169]

 HCC

Resistance

lncARSR

miR-34/ miR-449/ PTEN

92 NT

SMMC-7721 and HepG2 cell lines

lncARSR promoted PTEN mRNA degradation and modulated PTEN-PI3K/Akt pathway

[177]

 HCC

Resistance

MALAT1

miR-3129-5p / Nova1

36 patients

Huh-7 and Hep3B cell lines

MALAT1 knockdown suppressed proliferation, migration, invasion, and promoted apoptosis

[174]

 HCC

Resistance

NEAT1

–

HepG2, PLC/PRF/5, and Huh7 cell lines

NEAT1 up regulation in DOX resistant HCC cells

[175]

 HCC

Sensitivity

GAS5

miR-21/PTEN

HepG2 and HepB3 cell lines

GAS5 regulated PTEN expression through binding to miR-21 and reduced cell proliferation

[178]

 HCC

Sensitivity

H19

–

32 NT

H19 inhibited HCC cell proliferation following the doxorubicin treatments

[179]

Colorectal cancer (CRC)

 CRC

Resistance

XIST

miR-124

31 patients

HCT116 and LoVo cell lines

XIST inhibited miR-124 expression through sponging. XIST knockdown enhanced the anti-tumor effect of DOX

[187]

 CRC

Resistance

BANCR

miR-203

32 NT

HCT116, LoVo, NCM460 and HEK293T cell lines

BANCR knockdown suppressed tumor growth

[191]

 CRC

Resistance

GASS

NODAL

HCT116 cell line

GASS knockdown suppressed proliferation of cancer stem cells

[194]

Thyroid and gallbladder cancers

 ATC

Sensitivity

PTCSC3

STAT3/ INO80

20 FTC tissues and 20 ATC tissues

8505C, FTC 238, and FTC 133 cell lines

PTCSC3 regulated STAT3/ INO80 pathway and inhibited drug resistance

[203]

 GBC

Resistance

GBCDRlnc1

ATG5-ATG12

45 NT

NOZ and GBC-SD cell lines

GBCDRlnc1 knockdown inhibited autophagy

[205]

Prostate and urothelial cancers

 RCC

Resistance

LINC-PINT

EZH1/ EZH2

98 tumor tissues and 16 healthy tissues

HKC, 786-O, A498, 769P, Caki-2, Caki-1, ACHN, OS-RC-2, and SN12-PM6 cell lines

LINC-PINT knockdown decreased proliferation, cell progression, and promoted apoptosis

[208]

 BCa

Sensitivity

GAS5

BCL2

82 tumor tissues and 37 healthy tissues

BTCC T24, J82, CCC-HB-2, and T24/DOX cell lines

GAS5 knockdown increased BCL2 expression and apoptosis

[212]

 TCC

Resistance

HOTAIR

–

35 TCC tissues and 16 healthy tissues

TCC T24, J82, and SV-HUC-1 cell lines

HOTAIR knockdown inhibited cell proliferation and promoted apoptosis

[213]

 PCA

Resistance

LOXL1-AS1

miR-let-7a-5p

DU-145 and DU-145/DOX cell lines

LOXL1-AS1 knockdown inhibited cell proliferation and migration as well as promoted apoptosis

[219]