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Table 2 Studies about dysregulated circRNAs in OC

From: CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

Circular RNAs Models or sample types Regulation on expression Targeted miRNA Mechanism or effects on cancer progression References
Circ-SETDB1 SOC patients and healthy volunteers Upregulated It may act as a novel biomarker for finding SOC improvement and predicting reaction to platinum-taxane-combined chemotherapy and recurrence in SOC Wang et al. [73]
Circ-NFATC3 OC cell lines Upregulated It may play a promising role in increasing cell proliferation, migration and invasion in OC Karedathet al. [121]
Circ-0015756 OC and adjacent normal tissues
OC cell lines
Upregulated miR‑942-5p Suppressing Circ-0015756 inhibits OC promotion through the regulation of miR-942-5p/CUL4B pathway
Circ-0015756 may serve as a novel therapeutic target for OC
Du et al. [88]
Circ-0002711 OC tissues and cells
OC tissues and cell lines
Upregulated miR-1244 Circ-0002711/miR-1244/ROCK1 pathway regulates tumor growth in vivo Xie et al. [89]
Circ-0015326 Xenograft tumors in vivo Upregulated miR-127-3p Circ-0015326 facilizes OC progression through absorbing and adjusting the miR-127-3p/MYB pathway
Circ-0015326 may become a promising therapeutic target for OC
Zhang et al. [90]
Circ-0025033 OC tissues and cells Upregulated miR-330-5p MiR-330-5p acts as a tumor suppressor in OC through targeting KLK4
Circ-0025033 may be a candidate in diagnosis and therapeutic target in OC
Cheng  et al. [93]
Circ-0025033 OC tissues and cells Upregulated miR-184 Circ-0025033 accelerates the progression of OC through regulating LSM4 expression by absorbing miR-184
It provides a new therapeutic strategy for OC
Hou and Zhang [92]
Circ-MUC16 EOC tissues and healthy ovarian tissues
Cell lines
Upregulated miR-199a Circ-MUC16 promotes autophagy of EOC through absorbing miR-199a and regulation of ATG13 Gan et al. [76]
Circ-KRT7 OC cell lines Upregulated miR-29a-3p Circ-KRT7-miR-29a-3p-COL1A1 pathway increases tumorigenesis and promoting cell proliferation in OC An et al. [139]
Circ-0072995 EOC tissues and cell lines Upregulated miR-147a A novel diagnostic and therapeutic biomarker in OC
It Enhances the progression of EOC via modulating miR-147a/CDK6 pathway
Ding et al. [31]
Circ-FGFR3 OC tissues and their adjacent normal tissues Upregulated miR-29a-3p Regulating EMT of OC through miR-29a-3p/E2F1 pathway
Its overexpression relates to poor prognosis in OC patients
Zhou  et al. [83]
Circ-PGAM EOC tissues and cell lines Upregulated miR-542-3p Circ-PGAM1 accelerates malignant progression of EOC by modulation of the miR-542-3p/CDC5L/PEAK1 axis Zhang et al. [90]
Circ-ABCB10 EOC and adjacent normal tissues
EOC cell lines
Upregulated miR-1271
miR-1252
miR-203
Circ-ABCB10 relates to advanced clinicopathological features and unfavorable survival
It accelerates proliferation and reduce apoptosis through absorb of miR-1271, miR-1252 and miR-203 in EOC
Chen et al. [79]
Circ-ABCB10 EOC cells and normal epithelial ovarian cells Upregulated miR-1271 Circ-ABCB10 expression is associated with weak differentiation, progressive FIGO stage, and large tumor size by guiding the miR-1271-mediated Capn4/Wnt/β-catenin signaling pathway Lin et al. [84]
Circ-HIPK3 EOC tumor tissues and adjacent noncancerous tissues Upregulated Promoting proliferation, migration and invasion and inhibit apoptosis Teng et al. [32]
Circ-051239 EOC tissues and exosomes derived from plasma and cells
Cell lines in vitro
Upregulated miR-509-5p Superior metastatic EOC cells can admit this potential to lower metastatic potential through exosomal Circ-051239, generating raised proliferative, migratory and invasive inclusions in receptor cells Ma et al. [44]
Circ-EEF2 OC cell lines
and
In vivo tumor xenograft
Upregulated miR-6881-3p Circ-EEF2 increasing autophagy through absorbing miR-6881-3p and ANXA2 in EOC Yong et al. [81]
Circ-RAB11FIP1 EOC and normal tissue Upregulated miR-129 Circ-RAB11FIP1 increasing autophagy of OC via DSC1 and miR-129 and may serve as a potential biomarker for EOC diagnosis and targeted therapy Zhang et al. [82]
Circ-KIF4A OC tissues Upregulated miR-127 Promoting OC progression via miR-127/JAM3 axis
A promising novel biomarker and therapeutic target for OC
Sheng et al. [94]
Circ‑FAM53B OC specimens and cell lines Upregulated miR‑646
miR‑647
Contributing to oncogenesis through sponging miR-646 and miR-647 leading proliferation, migration, and invasion in OC Sun et al. [85]
Circ-Foxp1 Serum samples from EOC patients and healthy people Upregulated miR-22
miR-150-3p
Upregulated circulating exosomal Circ-Foxp1 is a self-determining prognosis of survival rate and drug resistance in EOC patients and can use as a novel biomarker and possible therapeutic target for EOC Luo and Gui [107]
Circ-S-7 OC and normal adjacent tissues Upregulated miR-641 Circ-S-7 promotes OC EMT by mediating miR-641 to up-regulate ZEB1 and MDM2 pathways Luo and Gui [107]
Circ-EPSTI1 OC tissues and cell lines Upregulated miR‐942 Circ-EPSTI1 adjusts OC promotion through decoying miR‐942
And can be serve as a biomarker and therapeutic target in OC
Xie et al. [89]
Circ-0061140 OC cell lines Upregulated miR-370 Regulating cell proliferation
in OC via mediation of the miR-370/ FOXM1 pathway
Chen et al. [79]
VPS13C/Circ-001567 Tumor and adjacent tissues
OC cell lines
Upregulated Knocking down of VPS13C/Circ-001567, reduces cell invasion, cell cycle, cell proliferation and apoptosis ability Bao et al. [66]
Circ-VPS13C OC cells Upregulated miR-145 Its Upregulation in OC
Accelerates the progression of OC
Circ-VPS13C/miR-145/MEK/ERK axis suppressed with the treatment of Propofol
Lu et al. [67]
RAD50/ Circ-00718 Tumor and adjacent tissues OC cell lines Upregulated It takes part in OC development via adjusting the biological behaviors of OC Bao et al. [66]
SPECC1/ Circ-000013 Tumor and adjacent tissues
and OC cell lines
Upregulated It takes part in OC development via adjusting the biological behaviors of OC Bao et al. [66]
Circ-CSPP1 OC tissues and cell lines Upregulated miR-1236-3p Increasing ZEB1 expression, EMT related markers, MMP-2 and VEGFA factors which are belong to tumorigenesis
Promoting cell proliferation and invasion by sponging miR-1236-3p
Li et al. [61]
Circ-PIP5K1A OC tissue and cell lines Upregulated miR-661 It contributes OC progression through targeting the miR-661/IGFBP5 pathway
Associated with poor prognosis
Sun et al. [77]
Circ-CELSR1 OC tissue and cell lines Upregulated miR-1252 Increasing of Circ-CELSR1 is associated with enhanced drug resistance through Circ-CELSR1/miR-1252/FOXR2 axis Zhang et al. [74]
Circ-CELSR1 OC tissue and cells Upregulated miR-149-5p Reducing cell sensitivity in to drug resistance by regulating miR-149-5p/SIK2 pathway Wei et al. [99]
Circ-GFRA1 OC tissues and adjacent normal tissues Upregulated miR-449a It acts as a novel biomarker in prognosis and therapeutic targets Liu et al. [55]
Circ-0013958 OC tissue and cell lines Upregulated Contributing OC promotion through affecting EMT and apoptosis
Circ-0013958 may serve as a novel diagnostic and therapeutic target in OC
Pei et al. [71]
Circ‑0005585 Normal ovarian tissue
Benign OC
tissue
Primary and metastatic EOC tissue
Upregulated miR-23a
miR-23b
miR-15a
miR-15b
miR-16
ESRP1 overexpression was regulated by Circ-0005585 via sponging miR-15a, miR-15b, miR-16, and miR-23a, miR-23b, which caused inhibition of cancer cells migration and metastasis Deng et al. [58]
Circ-102958 OC tissue and cell lines Upregulated miR-1205 Circ-102958 shows poor prognosis and promotes OC
progression by miR-1205/SH2D3A pathway
Wang et al. [59]
Circ-MYLK tumor tissue specimens and paracancerous
normal ones
Upregulated miR-652 Developing malignancy progression
of OC through absorbing miR-652
associating with pathological staging
and poor prognosis in OC patients
Zhao  et al. [60]
Circ-PUM1 OC tissues
Normal tissues
Cell lines
Upregulated miR-615-5p
miR-6753-5p
It acts as a cancer derive exosome
Promoting OC proliferation and migration
Guan et al. [72]
Circ-RhoC OC tissues
Normal tissues
Cell lines
Upregulated miR-302e Accelerating tumorigenicity via positive regulation of miR-302e/VEGFA axis Wang et al. [59]
Circ-0000714 OC cells
Cell lines
Upregulated miR-370-3p Controlling and Regulating RAB17/CDK6/RB axis
which progress in the malignancy of the paclitaxel-resistant OC cells
Guo et al. [100]
Circ-TNPO3 OC samples
and correlated with PTX resistance
Upregulated miR-1299 It plays a fundamental role in the chemoresistance and tumorigenesis of OC through upregulating NEK2 expression Xia et al. [101]
Circ-NRIP1 Tumor xenograft models Upregulated miR-211-5p It increasingly expresses in PTX-resistant OC tissues and cells
Suppressing of Circ-NRIP, inhibited the PTX resistance in OC through modulating the miR-211-5p/HOXC8 pathway
It may act as a prominent novel target in resistance therapy
Li et al. [102]
Circ-UBAP2 OC tissues
and adjacent normal tissues
Upregulated miR-144 Promoting OC progression via
sponging miR-144
Sheng et al. [94]
Circ-UBAP2 OC tissues and cell lines Upregulated miR-382-5p Promoting proliferation, migration and invasion and inhibit apoptosis Xu et al. [95]
Circ-0001068 OC patients and healthy volunteers Upregulated miR-28-5p Circ-0001068 was higher in OC patients than healthy ones
Play as a prominent noninvasive biomarker and aim for the diagnosis and therapeutic targets in OC
Wang et al. [106]
Circ-NOLC1 OC tissues
Normal tissues
Cell lines
Upregulated miR-326-5p
miR-330
miR-370
miR-9-5p
Increasing cell growth, migration, invasion, and playing an oncogenic role by attaching ESPR1, RhoA, and modulating CDK1 levels Chen et al. [108]
Circ-PVT1 EOC cell lines and Normal control cells Upregulated miR-149 Accelerating cell proliferation
hindering apoptosis
Sun et al. [85]
Circ-PVT1 OC tissue and normal tissue Upregulated miR-149-5p Increasing of PVT1 levels causes shorter survival rate in OC patients
Increasing FOXM1 level through binding to miR-149-5p
Causing OC cell viability and migration
Li et al. [86]
Circ-ASH2L OC cells in vitro
Tumor xenografts in vivo
Upregulated miR-665 Acting as a serious role in adjusting OC cell tumorigenesis, lymphangiogenesis and angiogenesis by the miR-665/VEGFA pathway
It is a thinkable candidate for therapeutic targets in OC
Chen et al. [79]
Circ-0051240 OC and corresponding adjacent non-cancerous tissues Upregulated miR-637 Boosting cell proliferation, migration and invasion in OC by miR-637/KLK4 pathway Zhang et al. [82]
Circ-SMAD7 OC cells and tissue Upregulated miR-630 Circ-SMAD7/miR-630/KLF axis causing oncogenic behavior in OC Zhao et al. [109]
Circ_0026123 OC cell lines and tissues Upregulated miR‑124‑3p Increasing OC cells metastasis and proliferation via the miR‑124‑3p/EZH2 axis Yang et al. [25]
Circ-WHSC1 normal ovaries and
OC tissues
Upregulated miR-145
miR-1182
Increasing expression of Circ-WHSC1 in OC promotes tumorigenesis via modulation of miR-145 and miR-1182 Zong et al. [64]
Circ-0009910 OC tissues
Normal ovarian tissues
OC cell lines
Upregulated miR-145 Circ-0009910, representing poor prognosis in OC cells
Inducing proliferation and motility
through suppressing miR-145
Li et al. [65]
Circ-0002711
Circ-0001756
OC patient serum Upregulated These CircRNAs are presumably related to OC promotion, and may be promising novel biomarkers Wang et al. [73]
Circ-0004390 OC tissue and normal tissue Upregulated miR-198 Circ-0004390 proliferation through miR-198/MET pathway, provides a therapeutic novel target for OC Xu et al. [57]
Circ-1656 SOC tissues and ovarian cell lines Downregulated Acting as a promising biomarker
and significantly associated with SOC FIGO stage
Gao et al. [112]
Circ-ITCH Tumor tissues and paired adjacent
tissues samples
Downregulated Suppressing cells proliferation
Increases cells apoptosis in EOC
Luo et al. [116]
Circ-ITCH Human EOC cell lines human normal ovarian epithelial cell line Downregulated miR-10a-α Suppressing cells proliferation
Increases cells apoptosis in EOC
Luo et al. [116]
Circ-ITCH OC tissues and cell lines Downregulated miR-145 Suppressing the malignancy of OC cells through the circ-ITCH-miR-145-RASA1 pathway Hu et al. [113]
Circ-ITCH OC tissues and cell lines Downregulated HULC-lncRNA It’s downregulation of OC with the mediate of HULC lncRNA Yan et al. [118]
Circ-9119 OC tissues and cell lines Downregulated miR-21 Regulating OC cells proliferation and apoptosis through absorbing miR-21 and targeting the PTEN–Akt axis Gong et al. [120]
Circ-LARP4 OC tissue and adjacent normal tissue samples Downregulated It’s Low expression in OC patients, makes it a novel prognostic biomarker Zou et al. [122]
CDR1as OC and EOC tissues and cell lines Downregulated miR-135b-5p By intermediation of miR-135-5p/ HIF1AN pathway, suppressing tumor formation Chen et al. [131]
Cdr1as OC tissues and cell lines Downregulated miR-1270 Reducing OC cells drug resistance by upregulation of SCAI and downregulation of miR-1270 Zhao et al. [109]
Circ-EXOC6B EOC specimens and normal ovarian tissues Downregulated It can play a role as a potential prognostic biomarkers in patients with EOC Ning et al. [110]
Circ-EXOC6B OC cells in vitro
OC cells in vivo
Downregulated miR-376c-3p Increasing sensitivity of drug resistance of OC cells
Decreasing proliferation, migration and invasion of OC cells through miR-376c-3p/FOXO3 axis
Zheng et al. [114]
Circ-EXOC6B Normal ovarian epithelial cells
Human OC cell lines
Downregulated miR-421 Promising target for the treatment of OC via sponging miR-421 and upregulating RSU1 Wang et al. [115]
Circ-BNC2 OC tissue and plasma samples Downregulated Potential diagnostic biomarkers in patients with EOC Hu et al. [113]
Circ-RHOBTB3 OC cells in vitro
OC cells in vivo
Downregulated Suppressing cell proliferation and metastasis
through PI3K/AKT signaling pathway
Hu et al. [113]
Circ-PLEKHM3 Primary OC/metastatic OC/normal ovarian tissues/cell lines Downregulated miR-9 Targeting miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis
Inactivates the PI3K/AKT and Wnt/catenin pathways via promoting BRCA1, DNAJB6a, and KLF4 expression by sponging miR-9
Zhang et al. [123]
Circ-0007444 OC patients and OC cells Downregulated miR-570-3p Circ-0007444 suppressing OC promotion through the miR-570-3p/PTEN pathway
It may serve as a candidacy for targeted therapy
Wu et al. [140]
Circ-ANKRD12 OC cell lines Downregulated miR-4768-5p Expression of Circ-ANKRD12, suppresses invasive molecular behaviors and phenotypes
Circ-ANKRD12 can act in a various set of tasks ranging from cell cycle arrest, tumor invasion to immune incorporation
Karedath et al. [121]
Circ-0078607 OC tissues and adjacent tissues
OC cell lines
Downregulated miR-518a-5p Circ-0078607 downregulation, inhibits
OC progression through miR-518a-5p/Fas axis
Zhang et al. [123]
Circ-0007874 OC cell lines Downregulated miR-760 Circ-0007874 downregulation, inhibits
OC progression through miR-760/SOCS3 pathway
Li et al. [125]
Circ-MTO1 OC tissues and adjacent tissues
OC cell lines
Downregulated miR-182-5p Circ-MTO1 suppresses the
proliferation and invasion of OC cells via the miR-182-5p/KLF15 pathway
Wang et al. [115]
Circ-100395 OC tissues Downregulated miR-1228 Circ-100395 suppresses cell proliferation and metastasis of OC cells through regulating the miR-1228/p53/EMT pathway Li et al. [125]