Table 2 Studies about dysregulated circRNAs in OC

Circ-SETDB1

SOC patients and healthy volunteers

Upregulated

–

It may act as a novel biomarker for finding SOC improvement and predicting reaction to platinum-taxane-combined chemotherapy and recurrence in SOC

Wang et al. [73]

Circ-NFATC3

OC cell lines

Upregulated

–

It may play a promising role in increasing cell proliferation, migration and invasion in OC

Karedathet al. [121]

Circ-0015756

OC and adjacent normal tissues

OC cell lines

Upregulated

miR‑942-5p

Suppressing Circ-0015756 inhibits OC promotion through the regulation of miR-942-5p/CUL4B pathway

Circ-0015756 may serve as a novel therapeutic target for OC

Du et al. [88]

Circ-0002711

OC tissues and cells

OC tissues and cell lines

Upregulated

miR-1244

Circ-0002711/miR-1244/ROCK1 pathway regulates tumor growth in vivo

Xie et al. [89]

Circ-0015326

Xenograft tumors in vivo

Upregulated

miR-127-3p

Circ-0015326 facilizes OC progression through absorbing and adjusting the miR-127-3p/MYB pathway

Circ-0015326 may become a promising therapeutic target for OC

Zhang et al. [90]

Circ-0025033

OC tissues and cells

Upregulated

miR-330-5p

MiR-330-5p acts as a tumor suppressor in OC through targeting KLK4

Circ-0025033 may be a candidate in diagnosis and therapeutic target in OC

Cheng  et al. [93]

Circ-0025033

OC tissues and cells

Upregulated

miR-184

Circ-0025033 accelerates the progression of OC through regulating LSM4 expression by absorbing miR-184

It provides a new therapeutic strategy for OC

Hou and Zhang [92]

Circ-MUC16

EOC tissues and healthy ovarian tissues

Cell lines

Upregulated

miR-199a

Circ-MUC16 promotes autophagy of EOC through absorbing miR-199a and regulation of ATG13

Gan et al. [76]

Circ-KRT7

OC cell lines

Upregulated

miR-29a-3p

Circ-KRT7-miR-29a-3p-COL1A1 pathway increases tumorigenesis and promoting cell proliferation in OC

An et al. [139]

Circ-0072995

EOC tissues and cell lines

Upregulated

miR-147a

A novel diagnostic and therapeutic biomarker in OC

It Enhances the progression of EOC via modulating miR-147a/CDK6 pathway

Ding et al. [31]

Circ-FGFR3

OC tissues and their adjacent normal tissues

Upregulated

miR-29a-3p

Regulating EMT of OC through miR-29a-3p/E2F1 pathway

Its overexpression relates to poor prognosis in OC patients

Zhou  et al. [83]

Circ-PGAM

EOC tissues and cell lines

Upregulated

miR-542-3p

Circ-PGAM1 accelerates malignant progression of EOC by modulation of the miR-542-3p/CDC5L/PEAK1 axis

Zhang et al. [90]

Circ-ABCB10

EOC and adjacent normal tissues

EOC cell lines

Upregulated

miR-1271

miR-1252

miR-203

Circ-ABCB10 relates to advanced clinicopathological features and unfavorable survival

It accelerates proliferation and reduce apoptosis through absorb of miR-1271, miR-1252 and miR-203 in EOC

Chen et al. [79]

Circ-ABCB10

EOC cells and normal epithelial ovarian cells

Upregulated

miR-1271

Circ-ABCB10 expression is associated with weak differentiation, progressive FIGO stage, and large tumor size by guiding the miR-1271-mediated Capn4/Wnt/β-catenin signaling pathway

Lin et al. [84]

Circ-HIPK3

EOC tumor tissues and adjacent noncancerous tissues

Upregulated

–

Promoting proliferation, migration and invasion and inhibit apoptosis

Teng et al. [32]

Circ-051239

EOC tissues and exosomes derived from plasma and cells

Cell lines in vitro

Upregulated

miR-509-5p

Superior metastatic EOC cells can admit this potential to lower metastatic potential through exosomal Circ-051239, generating raised proliferative, migratory and invasive inclusions in receptor cells

Ma et al. [44]

Circ-EEF2

OC cell lines

and

In vivo tumor xenograft

Upregulated

miR-6881-3p

Circ-EEF2 increasing autophagy through absorbing miR-6881-3p and ANXA2 in EOC

Yong et al. [81]

Circ-RAB11FIP1

EOC and normal tissue

Upregulated

miR-129

Circ-RAB11FIP1 increasing autophagy of OC via DSC1 and miR-129 and may serve as a potential biomarker for EOC diagnosis and targeted therapy

Zhang et al. [82]

Circ-KIF4A

OC tissues

Upregulated

miR-127

Promoting OC progression via miR-127/JAM3 axis

A promising novel biomarker and therapeutic target for OC

Sheng et al. [94]

Circ‑FAM53B

OC specimens and cell lines

Upregulated

miR‑646

miR‑647

Contributing to oncogenesis through sponging miR-646 and miR-647 leading proliferation, migration, and invasion in OC

Sun et al. [85]

Circ-Foxp1

Serum samples from EOC patients and healthy people

Upregulated

miR-22

miR-150-3p

Upregulated circulating exosomal Circ-Foxp1 is a self-determining prognosis of survival rate and drug resistance in EOC patients and can use as a novel biomarker and possible therapeutic target for EOC

Luo and Gui [107]

Circ-S-7

OC and normal adjacent tissues

Upregulated

miR-641

Circ-S-7 promotes OC EMT by mediating miR-641 to up-regulate ZEB1 and MDM2 pathways

Luo and Gui [107]

Circ-EPSTI1

OC tissues and cell lines

Upregulated

miR‐942

Circ-EPSTI1 adjusts OC promotion through decoying miR‐942

And can be serve as a biomarker and therapeutic target in OC

Xie et al. [89]

Circ-0061140

OC cell lines

Upregulated

miR-370

Regulating cell proliferation

in OC via mediation of the miR-370/ FOXM1 pathway

Chen et al. [79]

VPS13C/Circ-001567

Tumor and adjacent tissues

OC cell lines

Upregulated

–

Knocking down of VPS13C/Circ-001567, reduces cell invasion, cell cycle, cell proliferation and apoptosis ability

Bao et al. [66]

Circ-VPS13C

OC cells

Upregulated

miR-145

Its Upregulation in OC

Accelerates the progression of OC

Circ-VPS13C/miR-145/MEK/ERK axis suppressed with the treatment of Propofol

Lu et al. [67]

RAD50/ Circ-00718

Tumor and adjacent tissues OC cell lines

Upregulated

–

It takes part in OC development via adjusting the biological behaviors of OC

Bao et al. [66]

SPECC1/ Circ-000013

Tumor and adjacent tissues

and OC cell lines

Upregulated

–

It takes part in OC development via adjusting the biological behaviors of OC

Bao et al. [66]

Circ-CSPP1

OC tissues and cell lines

Upregulated

miR-1236-3p

Increasing ZEB1 expression, EMT related markers, MMP-2 and VEGFA factors which are belong to tumorigenesis

Promoting cell proliferation and invasion by sponging miR-1236-3p

Li et al. [61]

Circ-PIP5K1A

OC tissue and cell lines

Upregulated

miR-661

It contributes OC progression through targeting the miR-661/IGFBP5 pathway

Associated with poor prognosis

Sun et al. [77]

Circ-CELSR1

OC tissue and cell lines

Upregulated

miR-1252

Increasing of Circ-CELSR1 is associated with enhanced drug resistance through Circ-CELSR1/miR-1252/FOXR2 axis

Zhang et al. [74]

Circ-CELSR1

OC tissue and cells

Upregulated

miR-149-5p

Reducing cell sensitivity in to drug resistance by regulating miR-149-5p/SIK2 pathway

Wei et al. [99]

Circ-GFRA1

OC tissues and adjacent normal tissues

Upregulated

miR-449a

It acts as a novel biomarker in prognosis and therapeutic targets

Liu et al. [55]

Circ-0013958

OC tissue and cell lines

Upregulated

–

Contributing OC promotion through affecting EMT and apoptosis

Circ-0013958 may serve as a novel diagnostic and therapeutic target in OC

Pei et al. [71]

Circ‑0005585

Normal ovarian tissue

Benign OC

tissue

Primary and metastatic EOC tissue

Upregulated

miR-23a

miR-23b

miR-15a

miR-15b

miR-16

ESRP1 overexpression was regulated by Circ-0005585 via sponging miR-15a, miR-15b, miR-16, and miR-23a, miR-23b, which caused inhibition of cancer cells migration and metastasis

Deng et al. [58]

Circ-102958

OC tissue and cell lines

Upregulated

miR-1205

Circ-102958 shows poor prognosis and promotes OC

progression by miR-1205/SH2D3A pathway

Wang et al. [59]

Circ-MYLK

tumor tissue specimens and paracancerous

normal ones

Upregulated

miR-652

Developing malignancy progression

of OC through absorbing miR-652

associating with pathological staging

and poor prognosis in OC patients

Zhao  et al. [60]

Circ-PUM1

OC tissues

Normal tissues

Cell lines

Upregulated

miR-615-5p

miR-6753-5p

It acts as a cancer derive exosome

Promoting OC proliferation and migration

Guan et al. [72]

Circ-RhoC

OC tissues

Normal tissues

Cell lines

Upregulated

miR-302e

Accelerating tumorigenicity via positive regulation of miR-302e/VEGFA axis

Wang et al. [59]

Circ-0000714

OC cells

Cell lines

Upregulated

miR-370-3p

Controlling and Regulating RAB17/CDK6/RB axis

which progress in the malignancy of the paclitaxel-resistant OC cells

Guo et al. [100]

Circ-TNPO3

OC samples

and correlated with PTX resistance

Upregulated

miR-1299

It plays a fundamental role in the chemoresistance and tumorigenesis of OC through upregulating NEK2 expression

Xia et al. [101]

Circ-NRIP1

Tumor xenograft models

Upregulated

miR-211-5p

It increasingly expresses in PTX-resistant OC tissues and cells

Suppressing of Circ-NRIP, inhibited the PTX resistance in OC through modulating the miR-211-5p/HOXC8 pathway

It may act as a prominent novel target in resistance therapy

Li et al. [102]

Circ-UBAP2

OC tissues

and adjacent normal tissues

Upregulated

miR-144

Promoting OC progression via

sponging miR-144

Sheng et al. [94]

Circ-UBAP2

OC tissues and cell lines

Upregulated

miR-382-5p

Promoting proliferation, migration and invasion and inhibit apoptosis

Xu et al. [95]

Circ-0001068

OC patients and healthy volunteers

Upregulated

miR-28-5p

Circ-0001068 was higher in OC patients than healthy ones

Play as a prominent noninvasive biomarker and aim for the diagnosis and therapeutic targets in OC

Wang et al. [106]

Circ-NOLC1

OC tissues

Normal tissues

Cell lines

Upregulated

miR-326-5p

miR-330

miR-370

miR-9-5p

Increasing cell growth, migration, invasion, and playing an oncogenic role by attaching ESPR1, RhoA, and modulating CDK1 levels

Chen et al. [108]

Circ-PVT1

EOC cell lines and Normal control cells

Upregulated

miR-149

Accelerating cell proliferation

hindering apoptosis

Sun et al. [85]

Circ-PVT1

OC tissue and normal tissue

Upregulated

miR-149-5p

Increasing of PVT1 levels causes shorter survival rate in OC patients

Increasing FOXM1 level through binding to miR-149-5p

Causing OC cell viability and migration

Li et al. [86]

Circ-ASH2L

OC cells in vitro

Tumor xenografts in vivo

Upregulated

miR-665

Acting as a serious role in adjusting OC cell tumorigenesis, lymphangiogenesis and angiogenesis by the miR-665/VEGFA pathway

It is a thinkable candidate for therapeutic targets in OC

Chen et al. [79]

Circ-0051240

OC and corresponding adjacent non-cancerous tissues

Upregulated

miR-637

Boosting cell proliferation, migration and invasion in OC by miR-637/KLK4 pathway

Zhang et al. [82]

Circ-SMAD7

OC cells and tissue

Upregulated

miR-630

Circ-SMAD7/miR-630/KLF axis causing oncogenic behavior in OC

Zhao et al. [109]

Circ_0026123

OC cell lines and tissues

Upregulated

miR‑124‑3p

Increasing OC cells metastasis and proliferation via the miR‑124‑3p/EZH2 axis

Yang et al. [25]

Circ-WHSC1

normal ovaries and

OC tissues

Upregulated

miR-145

miR-1182

Increasing expression of Circ-WHSC1 in OC promotes tumorigenesis via modulation of miR-145 and miR-1182

Zong et al. [64]

Circ-0009910

OC tissues

Normal ovarian tissues

OC cell lines

Upregulated

miR-145

Circ-0009910, representing poor prognosis in OC cells

Inducing proliferation and motility

through suppressing miR-145

Li et al. [65]

Circ-0002711

Circ-0001756

OC patient serum

Upregulated

–

These CircRNAs are presumably related to OC promotion, and may be promising novel biomarkers

Wang et al. [73]

Circ-0004390

OC tissue and normal tissue

Upregulated

miR-198

Circ-0004390 proliferation through miR-198/MET pathway, provides a therapeutic novel target for OC

Xu et al. [57]

Circ-1656

SOC tissues and ovarian cell lines

Downregulated

–

Acting as a promising biomarker

and significantly associated with SOC FIGO stage

Gao et al. [112]

Circ-ITCH

Tumor tissues and paired adjacent

tissues samples

Downregulated

–

Suppressing cells proliferation

Increases cells apoptosis in EOC

Luo et al. [116]

Circ-ITCH

Human EOC cell lines human normal ovarian epithelial cell line

Downregulated

miR-10a-α

Suppressing cells proliferation

Increases cells apoptosis in EOC

Luo et al. [116]

Circ-ITCH

OC tissues and cell lines

Downregulated

miR-145

Suppressing the malignancy of OC cells through the circ-ITCH-miR-145-RASA1 pathway

Hu et al. [113]

Circ-ITCH

OC tissues and cell lines

Downregulated

HULC-lncRNA

It’s downregulation of OC with the mediate of HULC lncRNA

Yan et al. [118]

Circ-9119

OC tissues and cell lines

Downregulated

miR-21

Regulating OC cells proliferation and apoptosis through absorbing miR-21 and targeting the PTEN–Akt axis

Gong et al. [120]

Circ-LARP4

OC tissue and adjacent normal tissue samples

Downregulated

–

It’s Low expression in OC patients, makes it a novel prognostic biomarker

Zou et al. [122]

CDR1as

OC and EOC tissues and cell lines

Downregulated

miR-135b-5p

By intermediation of miR-135-5p/ HIF1AN pathway, suppressing tumor formation

Chen et al. [131]

Cdr1as

OC tissues and cell lines

Downregulated

miR-1270

Reducing OC cells drug resistance by upregulation of SCAI and downregulation of miR-1270

Zhao et al. [109]

Circ-EXOC6B

EOC specimens and normal ovarian tissues

Downregulated

–

It can play a role as a potential prognostic biomarkers in patients with EOC

Ning et al. [110]

Circ-EXOC6B

OC cells in vitro

OC cells in vivo

Downregulated

miR-376c-3p

Increasing sensitivity of drug resistance of OC cells

Decreasing proliferation, migration and invasion of OC cells through miR-376c-3p/FOXO3 axis

Zheng et al. [114]

Circ-EXOC6B

Normal ovarian epithelial cells

Human OC cell lines

Downregulated

miR-421

Promising target for the treatment of OC via sponging miR-421 and upregulating RSU1

Wang et al. [115]

Circ-BNC2

OC tissue and plasma samples

Downregulated

–

Potential diagnostic biomarkers in patients with EOC

Hu et al. [113]

Circ-RHOBTB3

OC cells in vitro

OC cells in vivo

Downregulated

–

Suppressing cell proliferation and metastasis

through PI3K/AKT signaling pathway

Hu et al. [113]

Circ-PLEKHM3

Primary OC/metastatic OC/normal ovarian tissues/cell lines

Downregulated

miR-9

Targeting miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis

Inactivates the PI3K/AKT and Wnt/catenin pathways via promoting BRCA1, DNAJB6a, and KLF4 expression by sponging miR-9

Zhang et al. [123]

Circ-0007444

OC patients and OC cells

Downregulated

miR-570-3p

Circ-0007444 suppressing OC promotion through the miR-570-3p/PTEN pathway

It may serve as a candidacy for targeted therapy

Wu et al. [140]

Circ-ANKRD12

OC cell lines

Downregulated

miR-4768-5p

Expression of Circ-ANKRD12, suppresses invasive molecular behaviors and phenotypes

Circ-ANKRD12 can act in a various set of tasks ranging from cell cycle arrest, tumor invasion to immune incorporation

Karedath et al. [121]

Circ-0078607

OC tissues and adjacent tissues

OC cell lines

Downregulated

miR-518a-5p

Circ-0078607 downregulation, inhibits

OC progression through miR-518a-5p/Fas axis

Zhang et al. [123]

Circ-0007874

OC cell lines

Downregulated

miR-760

Circ-0007874 downregulation, inhibits

OC progression through miR-760/SOCS3 pathway

Li et al. [125]

Circ-MTO1

OC tissues and adjacent tissues

OC cell lines

Downregulated

miR-182-5p

Circ-MTO1 suppresses the

proliferation and invasion of OC cells via the miR-182-5p/KLF15 pathway

Wang et al. [115]

Circ-100395

OC tissues

Downregulated

miR-1228

Circ-100395 suppresses cell proliferation and metastasis of OC cells through regulating the miR-1228/p53/EMT pathway

Li et al. [125]