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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Fig. 4

DIPS-associated changes in the protein level of kinases and transcription factors arbitrarily selected according to the literature as those being potentially involved in drug-induced cancer cell senescence. Representative bands corresponding to certain signaling molecules analyzed using western blot (a) and their densitometric analysis with GAPDH used as the reference protein (b). In order to reduce the risk of incorrect observations due to cellular hypertrophy in senescent cells, SDS-PAGE was performed using samples corresponding to the experimentally optimized number of cells (3–5 × 104). The results derive from 5–6 independent experiments on HGSOCs from different patients

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