Fig. 3
IC50 values for nutlin-3a across cancer types. Box-plot of IC50 values for human cancer cell lines divided by tissue subtype. Cell lines from each tissue subtypes are divided based on their TP53 status into wild type (red) and mutant/null (blue) groups. Differences in IC50 values between the two groups were evaluated by Mann–Whitney test; *p < 0.01. Data were obtained from Genomics of Drug Sensitivity in Cancer (dataset GDSC1; GDSC; [78]), and the IARC TP53 database (version R20, July 2019; [79]) was used for distribution according to p53 status