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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?

Fig. 5

Determinants of response to MDM2 inhibitors. The overall representation of factors determining sensitivity to MDM2 inhibitors divided into MDM2-dependent determinants, p53-dependent determinants, off-targets and other determinants. The determinants are divided into related groups of proteins. All of these factors were reported in the literature to affect the sensitivity to MDM2 inhibitors designed to disrupt the p53-MDM2 interaction interface

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