Fig. 5

Activated ESD induced by FPD5 inhibited cancer cell growth in vitro and in vivo. a FPD5 at 1–10 μM for 24 h decreased A549, H322 and HeLa cell viability. b The effect of FPD5 at 0.1–10 μM for 24 h on A549 cell viability in the presence of mTORC1 activator 3BDO. c–e FPD5 at different doses (10, 50, and 100 μM) reduced the size and weight of the tumor on CAM. Representative images are shown. Scale bar: 5 mm. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, N.S., not significant, n = 3