Fig. 3
From: Mitochondrial potassium channels: A novel calcitriol target
Effect of calcitriol on two-pore domain potassium channels from mitochondria isolated from human keratinocytes. A Recordings at + 40 mV in symmetrical (150/150 mM) KCl solutions with high calcium ion concentration (100 μM Ca2+, control) and low calcium concentration (10 μM Ca2+, control) and after application of 100 nM calcitriol. (o) indicates an open state of the channel. (c) indicates a closed state. Recordings are from one representative out of three independent experiments. B Bar graphs summarizing the effect of calcitriol on the open probability (Po) of the mitoTASK-3 channel and current amplitude (pA) in the presence of high and low calcium conditions. The left panel shows changes of Po after adding 30 nM, 100 nM, 300 nM calcitriol in the presence of high and low Ca2+ ion concentration (n = 3). The right panel shows changes in the current after adding 30 nM, 100 nM, 300 nM calcitriol in the presence of high and low Ca2+ ion concentration (n = 3)