Table 2 Modulating ROS to overcome cancer drug resistance
From: The role of polyphenols in overcoming cancer drug resistance: a comprehensive review
Mode of action | Compound | Application | Refs. |
|---|---|---|---|
TrxR | 2a, curcumin analoga | Sensitizes A549 cells to cisplatin | [203] |
10db | Effective on drug-sensitive (A549, SPC-A-1, LTEP-G-2) and drug-resistant (A549/DDP) lung cancer cells | [202] | |
Nrf2 | Curcumin | Mediates cisplatin chemoresistance in head and neck squamous cell carcinoma | [213] |
Reverses multidrug resistance in the HCT-8/5-Fu human colorectal cancer | [212] | ||
Resveratrol | Enhances the sensitivity of pancreatic cancer cells to gemcitabine | [214] | |
Chrysin | Reduces doxorubicin resistance by down-regulating Nrf2 signaling pathway in BEL-7402/ADM cells | [217] | |
GPX | ALZ003, curcumin analog | Suppresses growth of temozolomide-resistant glioblastoma | [216] |