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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation

Fig. 2

Molecular mechanisms associated with histone acetylation in β-catenin-TCF/LEF-dependent transcription of Wnt target genes. In the Wnt off state, TCF/LEF interacts with HADC1 and HADC2 to inhibit gene transcription by inhibiting acetylation of histone H3/H4. SIRT6 binds to β-catenin and participates in inhibition of β-catenin-TCF/LEF-dependent transcription. Bach1 binds to HDAC1 to suppress β-catenin. Pax7 inhibits the function of Barx2 in activating β-catenin, to block histone acetylation-associated gene transcription. In the Wnt on state, β-catenin interacts with TCF/LEF to release HDAC1 and HDAC2 to transcription factor binding sites. Additionally, β-catenin recruits p300, CBP, AKIP1, and Barx2 to facilitate histone acetylation at the target gene promoter. Pygo2 is also recruited by β-catenin to bind to p300 and GCN5 to promote histone acetylation to induce gene expression

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