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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma

Fig. 6

The JAK-STAT pathway is regulated by β3GNT2 in ESCA. A GSEA plot showing a positive correlation between β3GNT2 expression and the JAK-STAT pathway. B Heatmap showing the Spearman correlation coefficient between β3GNT2 and the JAK-STAT pathway-related genes in ESCA. Asterisks represent the significance of the Spearman correlation. C Analysis of the JAK-STAT pathway-related protein expression by Western blot. DG The effect of ruxolitinib on cell proliferation, colony formation, migration, and invasion was determined by CCK-8 assay (D), colony formation assay (E), Transwell migration assay (F), and Matrigel invasion assay (G). Cells were transfected with the indicated plasmids. shNC, negative control shRNA; shRNA, β3GNT2 shRNA2 lentiviral vector; Mock, empty plasmid; OV, pcDNA3.1/β3GNT2 plasmid. Data are expressed as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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