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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis

Fig. 5

SIX1 knockdown attenuated miR-524-5p inhibitor-mediated promotion of migration, invasion, and glycolysis. A The predictive binding of miR-524 and SIX1. B, C Levels of SIX1 in HepG2 cells with overexpression or silencing of miR-524. D miR-524 regulated luciferase activity of SIX1 3′-UTR. Effects of miR-524 inhibitor and SIX1 shRNA on (E, F) migration/invasion, (G) glucose uptake, (H) LDH activity, (I) lactate, and (J) ATP content, and (K, L) SIX1, MMP-2, MMP-9, HK2, and LDHA. The data are expressed as the mean ± SD (n = 3). ***P < 0.001 vs blank or NC. ###P < 0.001 vs miR-524 inhibitor

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