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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells

Fig. 4

Transcriptomics analysis implicates ERK pathway as a target of Slc25a5. After adipogenic differentiation, OP9 cells with or without Slc25a5 knockdown were collected, and a transcriptome analysis was performed. A PCA score plot showing clear clusters in each group. B Scatterplot of DEGs between the control and Slc25a5-knockdown cells (fold change ≥ 1.5, and P ≤ 0.06). C Heat map of the DEGs between the control and Slc25a5-knockdown cells. D GO analysis of downregulated DEGs. E Protein levels of ERK, p-ERK, P38, p-P38, JNK, p-JNK, and PPARγ were measured by western blot analysis. The values are the mean ± SEM (n = 3). *P < 0.05 versus control

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