Table 3 Exosomes containing let-7 family members in viral infections

HCV

Let-7a-5p

Let-7d-5p

Up

Plasma of chronic hepatitis

qRT-PCR

32

[262]

HCV

Let-7c-5p

Down

Plasma of chronic hepatitis

qRT-PCR

32

[262]

HCV

Let-7a-5p

Down

Serum of chronic hepatitis with liver cirrhosis

qRT-PCR

25

[133]

HCV/HEV

Let-7i

Down

Serum of blood donors

qRT-PCR

4

[328]

HIV

Let-7a

Let-7d

Let-7e

Let-7f

Let-7g

Let-7i

Up

Plasma of heroin abuse

Microarray

qRT-PCR

19

[329]

HIV/HCV

Let-7a-5p

Let-7b-5p

Let-7f-5p

Up

Blood

Sequencing

qRT-PCR

4

[263]

Japanese encephalitis virus

(JEV)

Let-7a

Let-7b

Up

N9 cells

qRT-PCR

–

[270]

Japanese encephalitis virus

(JEV)

Let-7g-5p

Up

CSF of acute encephalitis

qRT-PCR

16

[267]

HPV 18

Let-7d-5p

Down

HeLa cells

qRT-PCR

–

[330]

H1N1

Let-7b-5p

Down

BALF of influenza with acute respiratory distress syndrome (ARDS)

NGS

6

[331]

H7N7

Avian

Let-7a

–

A549 cells

Microfluidic microarray platform

–

[310]

H7N7

Avian

Let-7b

–

A549 cells

Microfluidic microarray platform

–

[310]

H7N7

Avian

Let-7c

–

A549 cells

Microfluidic microarray platform

–

[310]

H7N7

Avian

Let-7d

–

A549 cells

Microfluidic microarray platform

–

[310]

H7N7

Avian

Let-7e

–

A549 cells

Microfluidic microarray platform

–

[310]

H7N7

Avian

Let-7f

–

A549 cells

Microfluidic microarray platform

–

[310]

H7N7

Avian

Let-7i

–

A549 cells

Microfluidic microarray platform

–

[310]

H1N1

Swine/H7N7

Avian

Let-7g

–

A549 cells

Microfluidic microarray platform

–

[310]