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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses

Fig. 1

Protective effects of obacunone against lipopolysaccharide (LPS)-induced BEAS-2B damage. A, B LPS treatment decreased cell viability and increased lactate dehydrogenase (LDH) release as determined using Cell Counting Kit-8 (CCK-8) (A) and LDH (B) assays. C–G Obacunone (OB) increased cell viability (C), and inhibited LDH (D), IL-1β (E), IL-6 (F), and TNF-α (G) release in a dose-dependent manner (0, 10, 20, or 40 μM) following LPS treatment (10 μg/mL). H Representative EDU assay fluorescence images. I Representative flow cytometric images. Similar results were obtained from three independent experiments. All data are presented as mean ± standard error of the mean (SEM) (n = 6 for each group). #/*P < 0.05, ##/**P < 0.01, ###/***P < 0.001, # versus control group; * versus LPS group

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