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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses

Fig. 4

Ferroptosis was upregulated during lipopolysaccharide (LPS)-induced injury in vivo and in vitro. A Representative immunofluorescence images of GPX4 and 4-HNE in BEAS-2B cells. B, C Western blotting of GPX4 and SLC7A11 in mice (B) and BEAS-2B cells (C). D Expression levels of GPX4 in BEAS-2B cells as determined by RT-qPCR. E Expression level of Fe2+ in BEAS-2B cells. F Immunohistochemistry-based images of GPX4 and 4-HNE in the lung tissues. G Transmission electron microscopy (TEM) of ferroptosis in BEAS-2B cells. Similar results were obtained from three independent experiments. All data are presented as mean ± SEM (n = 6 for each group). ##/**P < 0.01, ###/***P < 0.001, # versus control group; * versus LPS group; ns, no significant difference between control and OB group

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