Fig. 7
Obacunone (OB) inhibited ferroptosis by activating nuclear factor-2 associated factor 2 (Nrf2). A Representative dihydroethidium (DHE) fluorescence images of the mouse lung tissues. B Representative hematoxylin and eosin (HE) staining images of the lung tissues. C Representative immunohistochemistry-based images of GPX4 and 4-HNE in the lung tissues. D Representative transmission electron microscopy (TEM) images of ferroptosis in BEAS-2B cells. E–G IL-1β, IL-6, and TNF-α concentrations in bronchoalveolar lavage fluid (BALF). H Fe2+ level in BEAS-2B cells. Similar results were obtained from three independent experiments. All data are presented as mean ± SEM (n = 6 for each group). ##/**P < 0.01, ###/***P < 0.001, # versus control group; * versus LPS + OB group