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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma

Fig. 3

The effects of growth factor signaling pathways. Representative western blots of ΔNp63 (72 kDa) in HaCaT, FaDu or SCC-25 cells grown for 16 h in 1% FBS and collected after a further 24 h of treatment with A the indicated growth factors (IGF1, insulin like growth factor-1; INS, insulin; EGF, epidermal growth factor; A, amphiregulin), B Cetuximab (CETUX), C BEZ235 (BEZ). β-actin (42 kDa) is shown as the loading control. CTR represents growth in standard medium (10% FBS); 0 represents growth in 1% FBS with no addition of growth factor or inhibitor. Relative ΔNp63 densitometry measurements normalized to β-actin are indicated for the representative blots shown, with 0 used as control. See Additional file 6 for other growth factors and Additional file 7 for the effects of inhibitors on downstream signaling pathways

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