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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: RETRACTED ARTICLE:Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1–AKT pathway

Fig. 2Fig. 2

Parecoxib-induced cell cycle arrest at G2 and inhibition of proliferation, invasion, and migration of ESCC cells. A, B Cell cycle phase distribution (A) and relative cell population (B) of parecoxib-treated KYSE30 and KYSE180 cells were determined by flow cytometry. C KYSE30 and KYSE180 cells treated with parecoxib (0, 100, 200, and 300 μM) were examined for colony formation. D Cell viability was determined by CCK8 assay after 24 h treatment with parecoxib (0, 100, 200, and 300 μM). E The difference in invasive ability of KYSE30 and KYSE180 cells treated with parecoxib (0, 100, 200, and 300 μM) was assessed by transwell invasion assay. F, G The difference in migratory ability of KYSE30 and KYSE180 cells treated with parecoxib (0, 100, 200 and 300 μM) was assessed by transwell migration assay (F) and wound healing assay (G). Images represent three independent experiments. Data are mean ± standard deviation of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001

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