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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages

Fig. 3

Transplantation of IL10-MSCs increased functional recovery in mice following SCI. A, B IL10-MSC treatment showed a statistically significant recovery over time with coordinated stepping (BMS ~ 7, **p < 0.01) and improved limb movement (BMS subscores ~ 7, **p < 0.01) at day 91 post-injury compared with MSC group. C, D Lesion sizes were quantified by immunostaining against GFAP, as depicted by the dotted white line. Image analysis revealed a significant decrease in mice treated with IL10-MSCs, compared with vehicle (***p < 0.001) and MSC groups (*p < 0.05). E, F Quantification of NF-positive staining revealed a greater increase in IL10-MSC group compared with vehicle (***p < 0.001) and MSC groups (**p < 0.01) (Scale bars, 250 and 50 μm). Data represent mean ± standard error of the mean (SEM) (ANOVA, ***p < 0.001, **p < 0.01, *p < 0.05. n = 6–8 mice per group)

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