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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: SETD8 cooperates with MZF1 to participate in hyperglycemia-induced endothelial inflammation via elevation of WNT5A levels in diabetic nephropathy

Fig. 3

SETD8 was involved in high-glucose-induced p-p65 and inflammatory factors levels through modulation of WNT5A levels in HGECs. a, b IHC expression of SETD8 in human and rat. c Western blot analysis of SETD8 and H4K20mel in HGECs. d mRNA expression of SETD8 in HGECs. e Western blot analysis of SETD8, WNT5A, and p-p65 in HGECs. f–i mRNA expression of SETD8, WNT5A, IL-6, and TNFα in HGECs. j SETD8 and H4K20mel were enriched in the WNT5A promoter (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n = 5 per group)

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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