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Table 4 Univariate and multivariable Cox proportional-hazards regression analysis on overall survival

From: Identification and validation of an eight-lncRNA signature that predicts prognosis in patients with esophageal squamous cell carcinoma

  Univariate analysis Multivariate analysis
Variables HR (95% CI) p-Value HR (95% CI) p-Value
Age (mean ± SD) 1.031 (1.008–1.053) 8.67 × 10−3* 1.027 (1.001–1.055) 4.26 × 10−2*
Gender (male/female) 0.782 (0.489–1.252) 3.05 × 10−1 NA NA
Alcohol (yes/no) 0.864 (0.588–1.269) 4.55 × 10−1 NA NA
Tobacco (yes/no) 0.749 (0.508–1.105) 1.44 × 10−1 NA NA
Pathologic N (N0/N1/N2/N3) 1.438 (1.181–1.751) 2.51 × 10−4* 1.025 (0.751–1.400) 8.75 × 10−1
Pathologic T (T1/T2/T3/T4) 1.187 (0.910–1.549) 2.05 × 10−1 NA NA
Pathologic stage (I/II/III/IV) 1.994 (1.398–2.846) 1.12 × 10−4* 1.904 (1.062–3.412) 4.58 × 10−2*
Arrhythmia (yes/no) 1.120 (0.727–1.725) 6.07 × 10−1 NA NA
Pneumonia (yes/no) 1.425 (0.719–2.823) 3.07 × 10−1 NA NA
Anastomotic leak (yes/no) 1.299 (0.603–2.798) 5.03 × 10−1 NA NA
Adjuvant therapy (yes/no) 2.264 (1.313–3.904) 2.53 × 10−3* 1.655 (0.982–2.787) 5.05 × 10−2
RS model status (high/low) 2.456 (1.651–3.654) 4.71 × 10−6* 2.205 (1.415–3.435) 4.73 × 10−4*
  1. *Statistically significant; RS risk score, HR hazard ratio, CI confidence interval, NA not analyzed