Fig. 5

The expression pattern of RAB11B-AS1 in HCC and its association with METTL16. A RAB11B-AS1 expression in human HCC tissues (n = 95) and normal liver tissues (n = 39) from GSE45436 dataset. ****P < 0.0001 by Mann–Whitney test. B RAB11B-AS1 expression level in 63 pairs of HCC tissues and matched adjacent noncancerous liver tissues was measured by RT-qPCR. **P < 0.01 by Wilcoxon signed-rank test. C Kaplan–Meier survival analysis of the correlation between RAB11B-AS1 expression and overall survival based on TCGA liver cancer data, analyzed by the online in silico tool Kaplan–Meier Plotter (https://kmplot.com/analysis/). D Kaplan–Meier survival analysis of the correlation between RAB11B-AS1 expression and overall survival in our HCC cohort. n = 63 patients with HCC. P = 0.0171 by log-rank test. Median RAB11B-AS1 level was used as cutoff. E The correlation between RAB11B-AS1 and METTL16 expression in 374 HCC tissues according to TCGA dataset, analyzed by the online in silico tool ENCORI. F The correlation between RAB11B-AS1 and METTL16 expression in 63 HCC tissues detected by qRT-PCR. r = −0.2753, P = 0.029 by Spearman correlation analysis