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Fig. 8 | Cellular & Molecular Biology Letters

Fig. 8

From: METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner

Fig. 8

RAB11B-AS1 reverses the oncogenic roles of METTL16 in HCC. A Migration ability of SNU-398 cells with METTL16 and RAB11B-AS1 concurrent overexpression or control was detected by transwell migration assay. Scale bars, 100 µm. B Invasion ability of SNU-398 cells with METTL16 and RAB11B-AS1 concurrent overexpression or control was detected by transwell invasion assay. Scale bars, 100 µm. C Cellular proliferation of SNU-398 cells with METTL16 and RAB11B-AS1 concurrent overexpression or control was detected by EdU assay. Scale bars, 100 µm. D Cellular proliferation of SNU-398 cells with METTL16 and RAB11B-AS1 concurrent overexpression or control was detected by CCK-8 assay. E Cellular apoptosis of SNU-398 cells with METTL16 and RAB11B-AS1 concurrent overexpression or control was detected by TUNEL assay. Scale bars, 100 µm. F Cellular apoptosis of SNU-398 cells with METTL16 and RAB11B-AS1 concurrent overexpression or control was detected by caspase-3 activity assay. Results are shown as mean ± SD of n = 3 independent experiments. **P < 0.01, ***P < 0.001; ns, not significant, by one-way ANOVA followed by Dunnett’s multiple comparisons test

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