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Fig. 10 | Cellular & Molecular Biology Letters

Fig. 10

From: Molecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis

Fig. 10

Mechanism of lncRNA SNHG12 in immune escape of NSCLC. SNHG12 was highly expressed in NSCLC. On the one hand, SNHG12 bound to HuR to improve mRNA stability and expression of PD-L1. On the other hand, lncRNA SNHG12 bound to HuR to improve mRNA stability and expression of USP8. USP8-mediated deubiquitination increased the protein level of PD-L1, consequently promoting immune escape of NSCLC

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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