Table 3 Impact of miRNA on angiogenesis under conditions of hypoxia

Increasing angiogenesis under hypoxia condition

miR-210-3p

miR-191

miR-24

Linking to HIF sites by HIF-1α and HIF-2α chromatin immunoprecipitation (ChIP)-sequence analysis

Stimulation of TGF-β-signaling pathways

Increasing the level of genes pertaining to TGFβ-signaling pathways, namely TGFβ2, SMAD3, BMP4, JUN, FOS, PTGS2, CTGF, and VEGFA

Increasing formation of mammospheres

Escalating the expression of Nanog and Oct-3/4 stemness genes

Decreasing the expression of pro-apoptotic BimL

Increasing the levels of two HIF-1α direct targets, Snail and VEGFA

[47, 89, 90]

Decreasing angiogenesis under hypoxia condition

miR-140-5p

miR-29b

miR-497

Inhibiting VEGFA expression

Decreasing the expression of proteins such as CD31, Ki-67, and MMP-9

Targeting AKT3 protein

Promoting VEGF and c-MYC arrest

Upregulating VEGF and HIF-1α

[91,92,93]