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Table 2 Identified genes involved in drug resistance using CRISPR/Cas9 technology

From: CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer

Genes responsible for drug resistance

Type of cancer cell

Possible effects

References

SLFN11

Lung cancer

Enhancing S-phase arrest

Enhancing apoptosis

Attenuating resistance to talazoparib

[154, 155]

APE1

Triple-negative breast cancer

Attenuating resistance to olaparib

[156]

RSF1

Lung cancer

Enhancing NFKB signaling

Enhancing paclitaxel resistance

[158]

CDK5

Hepatocellular carcinoma

Enhancing sorafenib resistance

[161]

ARID1A

Endometrial cancer

Upregulating PRB

Enhancing cancer cell sensitivity to MPA

[163]

Aurora-B

Lung cancer

Attenuating the p53-dependent DNA damage response

Enhancing resistance to cisplatin and paclitaxel

[164]

ATRX

Glioma

Enhancing ATM-dependent DNA repair

Enhancing resistance to TMZ

[167]

BIRC5

Ovarian cancer

Enhancing EMT

Enhancing paclitaxel resistance

[169]

PBRM1

Lung cancer

Attenuating AKT signaling

Enhancing effectiveness of EGFR inhibitors

[174]

SGOL1

Hepatocellular carcinoma

Enhancing cytotoxic effect of sorafenib

[177]

Tceal1

Prostate cancer

Increasing cell death, polyploidy, and docetaxel sensitivity might happen after knockout

[178]

ABCC9 and IL37

Cervical cancer

Paclitaxel resistance

[179]

MSH2

Bladder cancer

Reducing apoptotic effect of cisplatin might happen after gene knockout

[180]

ELP5

Gallbladder cancer

Poor survival might happen after ELP5 knockout and gemcitabine treatment

[181]

Farnesyltransferase

Renal cell carcinoma

Sunitinib resistance

[182]

FBXO42

NRAS-mutant melanoma

Trametinib resistance

[183]

LZTR1, NF1, and TSC1 or TSC2

Acute myeloid leukemia

Sorafenib resistance

[184]

BEND3

Acute myeloid leukemia

Increasing ABCG2 level, reducing TAK-243 in the cell and drug resistance

[185]

Wnt/B-catenin

k-ras mutated colorectal cancer

ABT-263 resistance

[186]

MSH2, CLCA2, and PTCH2

Glioblastoma

TMZ resistance

[187]