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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy

Fig. 1

WTAP is highly expressed in DN tissues and HG-induced HK-2 cells. A m6A levels in control (n = 10) and DN tissues (n = 63) measured by ELISA. B, C mRNA expression of METTL3 and WTAP in the control (n = 10) and DN tissues (n = 63) measured by real-time (RT)-qPCR. D, E Pearson correlation scatter plots (n = 63). F, G Protein expression of WTAP in the control (n = 10) and DN tissues (n = 63) measured by immunohistochemical staining. Scale bar, 50 μm. (H–J) mRNA and protein expression of WTAP in NG- or HG-induced HK-2 cells measured by RT-qPCR and western blot (n = 3). Unpaired Student’s t-test was used for the analysis between two groups, and one-way analysis of variance was used to analyze the data among multiple groups, followed by Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control or 0 h

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