Fig. 3
From: WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
WTAP overexpression promotes cell pyroptosis and pro-inflammatory factor release in HK-2 cells. A Cell viability; (B, C) cell pyroptosis; (D) LDH activity; (E, F) expression of WTAP, NLRP3, pro-caspase-1, active caspase-1, GSDMD and GSDMD-N; and (G, H) the release of IL-18, IL-1β, TNF-α, and IL-6 in HK-2 cells with or without WTAP overexpression (n = 3). Unpaired Student’s t-test was used for the analysis between two groups. **P < 0.01, ***P < 0.001 compared with vector