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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy

Fig. 7

Histone acetyltransferase p300 promotes the transcription of the WTAP promoter through H3K27 acetylation. HG-induced HK-2 cells were treated with 10 μM histone acetyltransferase p300 inhibitor (C646). A–C WTAP expression and H3K27 acetylation (H3K27ac). D H3K27ac at WTAP promoter region. E Luciferase activity of WTAP promoter in H3 wild type (wtH3) or K27R-mutant (K27R) HK-2 cells treated with 10 μM C646 (n = 3). F Schematic diagram of the relationship between WTAP, m6A modification, HK-2 cell pyroptosis, and inflammation. One-way analysis of variance was used to analyze the data among multiple groups, followed by Tukey’s post hoc test. *P < 0.05, ***P < 0.001 compared with 0 h

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