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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

Fig. 1

Effects of CAF differentiation in the TME. Toxic TME drives metabolic reprogramming in the normal fibroblast towards the catabolic CAF. These cells are highly glycolytic, providing lactate and ketone bodies to fuel tumor growth and progression. The aberrant secretome of CAFs (also referred to as “cancer cell secretome”) contributes to metabolic stress in the TME and also inhibits the function of effector T cells and enables iTreg differentiation. CXCL12 C-X-C motif chemokine 12, IDO indoleamine 2,3-dioxygenase, IL interleukin, iTreg induced regulatory T cells, TGF transforming growth factor, TME tumor microenvironment; for other abbreviations, see Abbreviation section

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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