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Table 1 Correlations of BP1 and DLX7 expression with clinical characteristics and laboratory results of CML patients

From: DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis

Patient characteristic

BP1 expression

DLX7 expression

High (n = 25)

Low (n = 50)

P

Low (n = 39)

High (n = 36)

P

Sex, male/female

16/9

33/17

1.000

26/13

23/13

0.813

Median age, years (range)

54 (25–75)

53.5 (15–83)

0.698

48 (22–76)

52.5 (15–67)

0.150

Median WBC, × 109/L (range)

65.3 (25.1–298.6)

70.3 (20–412.8)

0.348

73.1 (24.5–413.8)

60.9 (21.7–321.9)

0.627

Median hemoglobin, g/L (range)

97 (70–134)

92 (57–145)

0.908

92 (57–145)

96.5 (66–134)

0.585

Median platelets, × 109/L (range)

277 (16–1175)

367 (40–1004)

0.230

259 (40–1006)

373.5 (16–1175)

0.597

Cytogenetics

  

0.227

  

0.975

 t(9;22)

16

35

 

27

24

 

 t(9;22) with additional alteration

5

3

 

4

4

 

 Normal karyotype

2

3

 

2

3

 

 No data

2

9

 

6

5

 

Staging

  

0.602

  

0.008

 CP

20

40

 

26

34

 

 AP

1

5

 

5

1

 

 BC

4

5

 

8

1

 

Median BCR/ABL transcript, % (range)

164.1 (13.81–14,464.68)

136.74 (16.87–3211)

0.933

216.47 (16.87–3211.00)

93.285 (13.81–14,464.68)

0.054

  1. WBC, white blood cells; CP, chronic phase; AP, accelerated phase; BC, blast crisis