Condition | Model | Cell source | Administration route | Results | Ref. |
---|---|---|---|---|---|
AD | 3xTg mice | BM | Intranasal | Induction of neuroprotection by provoking anti-inflammatory effect | [92] |
AD | APP/PS1 mice | BM | Intravenous | Amelioration in learning and memory capabilities, reducing Aβ levels and supporting anti-inflammatory environment | [217] |
AD | APP/PS1 mice | BM | Intravenous | Cognitive impairment rescue by improving microRNA-146a levels in the hippocampus | [105] |
AD | Aluminum chloride-injected rat | BM | Intravenous | Pathological symptoms rescue | [218] |
PD | 6-OHDA rat | BM | Intravenous | Attenuation of dopaminergic neuron loss in SN, and improving dopamine levels in the striatum | [93] |
PD | 6-OHDA rat | BM | Intravenous | Neuroprotective effect on dopaminergic neuron | [219] |
PD | MPTP mice | AT | Intravenous | Suppression of autophagy and pyroptosis | [155] |
PD | MPTP mice | AT | Intraperitoneal | Promotion of the angiogenesis of human brain microvascular endothelial cells (HBMECs) | [95] |
PD | 6-OHDA rat | AT | NA | Induction of neuroprotection by upregulation of the sirtuin 3 (SIRT3) levels | [220] |
PD | 6-OHDA rat | BM | Intravenous | Improving motor function | [221] |
PD | 6-OHDA rat | BM | Intranigral Intrastriatal | Reverting motor phenotype and the neuronal organization | [222] |
PD | α-Syn induced C. elegans | BM | NA | Reduced number of α-syn inclusions | [153] |
HD | R6/2 mice | AM | Intraperitoneal | Amelioration of neurological complications rotarod function | [162] |
ALS | SOD1G93A mice | AT | Intravenous Intranasal | Inhibition of glial cells activation, supporting motor neuron rescue, and protecting the neuromuscular junction | [161] |