Table 4 Summary of important clinical trials based on MSC therapy in common neurodegenerative diseases (April 2022)
Condition | Phase | Cell source | Administration route | Participant number | Status | Location | NCT number |
|---|---|---|---|---|---|---|---|
AD | 1 | UCB | NA | 9 | Completed | South Korea | NCT01297218 |
AD | 2 | UC | Intravenous | 40 | Recruiting | USA | NCT02833792 |
AD | 1 | UC | Intravenous | 6 | Recruiting | USA | NCT04040348 |
AD | 2 | AT | Intravenous | 80 | Not yet recruiting | South Korea | NCT04482413 |
AD | 1/2 | AT-exosome | Intranasal | 9 | Recruiting | China | NCT04388982 |
AD | 1/2 | AT | Intravenous | 21 | Completed | USA | NCT03117738 |
AD | 1/2 | UC | Intravenous | 24 | Recruiting | South Korea | NCT02899091 |
AD | 1/2 | UCB | Intraventricular | 46 | Completed | South Korea | NCT02054208 |
PD | 1 | BM | Intravenous | 20 | Completed | USA | NCT02611167 |
PD | 1/2 | UC | Intrathecal Intravenous | 10 | Active, not recruiting | Jordan | NCT03684122 |
PD | NA | BM | Intrastriatal | 5 | Terminated | India | NCT00976430 |
PD | 2 | UC | Intravenous | 45 | Active, not recruiting | USA | NCT04506073 |
PD | 1 | UC | Intravenous | 20 | Enrolling by invitation | China | NCT03550183 |
PD | 2/3 | BM | Intravenous | 50 | Recruiting | Belarus | NCT04146519 |
PD | 1 | AT | Intracranial | 9 | Not yet recruiting | Taiwan | NCT05094011 |
PD | NA | AT UC | Intrathecal Intravenous | 15 | Recruiting | Indonesia | NCT04876326 |
ALS | 1/2 | BM | Intrathecal | 20 | Completed | Israel | NCT04821479 |
ALS | 1 | AT | Intravenous | 19 | Completed | Iran | NCT02492516 |
ALS | 1 | BM | Intrathecal | 8 | Completed | Iran | NCT01771640 |
ALS | 1/2 | WJ | Intrathecal | 20 | Recruiting | Poland | NCT04651855 |
ALS | 1 | AT | Intrathecal | 27 | Completed | USA | NCT01609283 |
ALS | 1 | NA | Intrathecal | 3 | Completed | Brazil | NCT02987413 |
ALS | 2 | BM | Intramuscular Intrathecal | 48 | Completed | USA | NCT02017912 |
ALS | 3 | BM | Intrathecal | 263 | Completed | USA | NCT03280056 |
ALS | 1/2 | AT | Intravenous | 52 | Active, not recruiting | Spain | NCT02290886 |
ALS | 1 | AT | Intraspinal | 30 | Active, not recruiting | Poland | NCT03296501 |