Fig. 1

Cell viability of different NSCLC cells treated with three borneol forms and cotreatment with d-borneol and CDDP, and effect on cell proliferation, P-gp function, and cell migration in H460/CDDP cells. A A549 and H460 cells cultured with different concentrations of d-borneol, l-borneol, and SB for 24 h; B H460 was treated with d-borneol, l-borneol, and SB for 24 h and 48 h, and cell viability was determined by MTT; C cell viability of H460 and H460/CDDP cells treated with different concentrations of CDDP for 24 h; D cell viability of CDDP on H460/CDDP cells for 24 h and 48 h; E cytotoxicity of the three borneol forms on H460/CDDP cells; F, G cell viability (F) and cell morphology (G) of H460/CDDP cells treated with CDDP (10 μg/ml), or d-borneol (0.5, 1, 2, and 4 μg/ml) + CDDP (10 μg/ml) for 24 h; H determination of P-gp function after treatment with CDDP, CDDP plus d-borneol with different concentrations for 24 h; I–K mRNA expression (I) and protein expression (J, K) of P-gp; L, M cell migration of H460/CDDP cells; N representative photographs showing colony formation after CDDP cotreatment with d-borneol in H460/CDDP cells; O calculation of statistical differences. All data are presented as mean ± SD (n = 3, *P < 0.05, compared with Con; ^#P < 0.05, compared with CDDP group)