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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage

Fig. 2

Transcriptomic and gene enrichment analysis upon AT treatment in OA chondrocyte cells. A Heatmap of expression of transcripts from triplicate experiments of OA and OA + AT. B Volcano plot of differential expressed genes. Yellow points represent upregulated genes for log2FC > 2, and blue points represent upregulated genes for log2FC < -2. C GSEA analysis of negative regulated genes shows PI3K–AKT–mTOR signaling. D The analysis of KEGG pathway enrichment for negative regulated genes. P13K-AKT-mTOR signaling pathway was enriched from these negative regulated genes. E Waterfall plot of fold change in gene expression in OA chondrocyte cells treated with 0.05 µM AT for 6 h; selected TNFSF11 gene is highlighted

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