Fig. 4From: Aging of mesenchymal stem cell: machinery, markers, and strategies of fightingOverview of replicative senescence markers in MSCs. The major markers of MSC aging in laboratory are DNA damage, P53 upregulation,  SA-β-gal expression, morphological changes, cell-cycle arrest, skewed differentiation, induced SASP, and compromised colony-forming ability. Activate ( )Back to article page