Fig. 1
From: The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges
The biosynthesis process of microRNAs. This multistep maturation process includes the production of the pri-miRNA transcript by RNA Pol II&III and cleavage of the pri-miRNA by the microprocessor complex (Drosha and DGCR8) in the nucleus. The resulting pre-miRNAs are exported from the nucleus via Exportin-5. In the cytoplasm, the RNase Dicer forms a complex and cleaves the pre-miRNA hairpin to its mature length. The functional strand of the mature miRNA is combined with Ago2 into the RISC, where it guides it to induce silencing of target mRNAs through mRNA cleavage, translational repression, or deadenylation